The prevalence of resistant nosocomial infections in the intensive care unit of a versatile hospital
Abstract
A study of biotypes of patients in intensive care unit (ICU) of a versatile hospital has been conducted. There has been conducted the taking of pathological material from different biotypes (bronchoalveolar lavage, the contents of drainage, wound discharge, urine, feces) of patients with abdominal infection, head injury, ICU patients with manifestation of nosocomial infections, as well as definition of sensitivity of microorganisms to antibiotics was also conducted. As a result of the study the prevalence of gram-negative microflora in the etiological structure of nosocomial infections in the ICU was revealed. In assessing the risk stratification of groups of patients with nosocomial infections and invasive candidiasis, it was noted that most of the patients corresponded to the third group of the stratification. The study revealed that 40% of strains of K. pneumonia and 25% E. coli are the producers of β-lactamase extended spectrum (ESBL).
References
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4. Rudnov V.A. Modern clinical significance of Pseudomonas infection and the possibility of treatment in patients intensive care departments. // Infekcii i Antimikrobnaja Terapija. – 2002. - № 6. – P. 170-177. (in Russian)
5. Yakovlev S.V. Time to re-evaluate the place of carbapenems in nosocomial infections. // Russkij Medicinskij Zhurnal. – 2006. – Vol. 14. №5. – P. 376-380. (in Russian)
6. Ben-Ami R., Schwaber M.J., Navon-Venezia S., et al. Influx of extended-spectrum beta-lactamase-producing enterobacteriaceae into the hospital. // Clin Infect Dis. – 2006. – Vol. 42(7). – P. 925-934.
7. Center for Disease Control and Prevention, USA. – URL: www.cdc.gov
8. Carmeli Y. Predictive factors for multidrug-resistant organisms. In: Role of Ertapenem in the Era of Antimicrobial Resistance [newsletter]. – URL: http://www.invanz.co.il/secure/downloads/IVZ_Carmeli_NL_2006_W-226364-NL.pdf.
9. Dimopoulos G., Karabinis A., Samonis G., Falagas M.E. Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study. // Eur J Clin Microbiol Infect Dis. – 2007. – Vol. 26 (6). – P. 377-384.
10. Garner J.S., Jarvios W.R., Emori T.G., et al. CDC definition for nosocomial infections // Am J Infect Control. – 1988. – Vol. 16. – P. 128-140.
11. Pop-Vicas A.E., D’Agata E.M.C. The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital. // Clin Infect Dis. – 2005. – Vol. 40(12). – P. 1792-1798.
12. Poulou A., Voulgary E., Vrioni G., et al. Imported KPC-produsing Klebsiella pneumonia clones in a Greek hospital: impact of infections control measures to restrain their dissemination // J. Clin. Microbiol. – 2012. – Vol. 50. – P. 2618-2623. – doi: 10.1128/JCM.00459-12
13. Rello J., Ollendorf D.A., Oster G., et al. Epidemiology and outcomes of ventilator associated pneumonia in a large US database // Chest. – 2002. – Vol. 122 (6). – P. 2115-2122.
14. Shah P.M. Parenteral carbapenems. // Clin Microbiol Infect. – 2008. – Vol. 14(suppl 1). – P. 175-180.
15. Snitkin E.S., Zelazny A.M., Thomas P.J., Stock F.; NISC Comparative Sequencing Program group, Henderson D.K., Palmore T.N., Segre J.A. Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumonia with Whole-Genom Sequencing // Sci. Transl. Med. – 2012. – Vol. 4 (148). – P. 148ra116. – doi: 10/1126/scitranslme.
2. Козлов Р.С. Нозокомиальные инфекции: эпидемиология, патогенез, профилактика, контроль. // Клиническая микробиология и антимикробная химиотерапия. – 2000. - №11. – С. 16-30.
3. Монисов А.А., Лазикова Г.Ф., Фролочкина Т.Н., Коршунова Г.С. Состояние заболеваемости внутрибольничными инфекциями в Российской Федерации. // Эпидемиология и инфекционные болезни. – 2000. - № 5. – С. 9-12.
4. Руднов В.А. Современное клиническое значение синегнойной инфекции и возможности ее терапии у пациентов отделений реанимации. // Инфекции и антимикробная терапия. – 2002. - № 6. – С. 170-177.
5. Яковлев С.В. Время для переоценки места карбапенемов при нозокомиальных инфекциях. // Русский медицинский журнал. – 2006. – Т. 14. №5. – С. 376-380.
6. Ben-Ami R., Schwaber M.J., Navon-Venezia S., et al. Influx of extended-spectrum beta-lactamase-producing enterobacteriaceae into the hospital. // Clin Infect Dis. – 2006. – Vol. 42(7). – P. 925-934.
7. Center for Disease Control and Prevention, USA. – URL: www.cdc.gov
8. Carmeli Y. Predictive factors for multidrug-resistant organisms. In: Role of Ertapenem in the Era of Antimicrobial Resistance [newsletter]. – URL: http://www.invanz.co.il/secure/downloads/IVZ_Carmeli_NL_2006_W-226364-NL.pdf.
9. Dimopoulos G., Karabinis A., Samonis G., Falagas M.E. Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study. // Eur J Clin Microbiol Infect Dis. – 2007. – Vol. 26 (6). – P. 377-384.
10. Garner J.S., Jarvios W.R., Emori T.G., et al. CDC definition for nosocomial infections // Am J Infect Control. – 1988. – Vol. 16. – P. 128-140.
11. Pop-Vicas A.E., D’Agata E.M.C. The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital. // Clin Infect Dis. – 2005. – Vol. 40(12). – P. 1792-1798.
12. Poulou A., Voulgary E., Vrioni G., et al. Imported KPC-produsing Klebsiella pneumonia clones in a Greek hospital: impact of infections control measures to restrain their dissemination // J. Clin. Microbiol. – 2012. – Vol. 50. – P. 2618-2623. – doi: 10.1128/JCM.00459-12
13. Rello J., Ollendorf D.A., Oster G., et al. Epidemiology and outcomes of ventilator associated pneumonia in a large US database // Chest. – 2002. – Vol. 122 (6). – P. 2115-2122.
14. Shah P.M. Parenteral carbapenems. // Clin Microbiol Infect. – 2008. – Vol. 14(suppl 1). – P. 175-180.
15. Snitkin E.S., Zelazny A.M., Thomas P.J., Stock F.; NISC Comparative Sequencing Program group, Henderson D.K., Palmore T.N., Segre J.A. Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumonia with Whole-Genom Sequencing // Sci. Transl. Med. – 2012. – Vol. 4 (148). – P. 148ra116. – doi: 10/1126/scitranslme.
REFERENCES
1. Vladimirov N.I. Epidemiology of nosocomial infections: the concept of sanitary and epidemiological surveillance. – Irkutsk, 2003. (in Russian)
2. Kozlov R.S. Nosocomial infections: epidemiology, pathogenesis, prevention, control. // Klinicheskaja Mikrobiologija i Antimikrobnaja Himioterapija. – 2000. - №11. – P. 16-30. (in Russian)
3. Monisov A.A., Lazikova G.F., Frolochkina T.N., Korshunova G.S. Status incidence of nosocomial infections in the Russian Federation. // Jepidemiologija i Infekcionnye Bolezni. – 2000. - № 5. – P. 9-12. (in Russian)
4. Rudnov V.A. Modern clinical significance of Pseudomonas infection and the possibility of treatment in patients intensive care departments. // Infekcii i Antimikrobnaja Terapija. – 2002. - № 6. – P. 170-177. (in Russian)
5. Yakovlev S.V. Time to re-evaluate the place of carbapenems in nosocomial infections. // Russkij Medicinskij Zhurnal. – 2006. – Vol. 14. №5. – P. 376-380. (in Russian)
6. Ben-Ami R., Schwaber M.J., Navon-Venezia S., et al. Influx of extended-spectrum beta-lactamase-producing enterobacteriaceae into the hospital. // Clin Infect Dis. – 2006. – Vol. 42(7). – P. 925-934.
7. Center for Disease Control and Prevention, USA. – URL: www.cdc.gov
8. Carmeli Y. Predictive factors for multidrug-resistant organisms. In: Role of Ertapenem in the Era of Antimicrobial Resistance [newsletter]. – URL: http://www.invanz.co.il/secure/downloads/IVZ_Carmeli_NL_2006_W-226364-NL.pdf.
9. Dimopoulos G., Karabinis A., Samonis G., Falagas M.E. Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study. // Eur J Clin Microbiol Infect Dis. – 2007. – Vol. 26 (6). – P. 377-384.
10. Garner J.S., Jarvios W.R., Emori T.G., et al. CDC definition for nosocomial infections // Am J Infect Control. – 1988. – Vol. 16. – P. 128-140.
11. Pop-Vicas A.E., D’Agata E.M.C. The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital. // Clin Infect Dis. – 2005. – Vol. 40(12). – P. 1792-1798.
12. Poulou A., Voulgary E., Vrioni G., et al. Imported KPC-produsing Klebsiella pneumonia clones in a Greek hospital: impact of infections control measures to restrain their dissemination // J. Clin. Microbiol. – 2012. – Vol. 50. – P. 2618-2623. – doi: 10.1128/JCM.00459-12
13. Rello J., Ollendorf D.A., Oster G., et al. Epidemiology and outcomes of ventilator associated pneumonia in a large US database // Chest. – 2002. – Vol. 122 (6). – P. 2115-2122.
14. Shah P.M. Parenteral carbapenems. // Clin Microbiol Infect. – 2008. – Vol. 14(suppl 1). – P. 175-180.
15. Snitkin E.S., Zelazny A.M., Thomas P.J., Stock F.; NISC Comparative Sequencing Program group, Henderson D.K., Palmore T.N., Segre J.A. Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumonia with Whole-Genom Sequencing // Sci. Transl. Med. – 2012. – Vol. 4 (148). – P. 148ra116. – doi: 10/1126/scitranslme.
Published
2018-04-16
How to Cite
ПРОСТАКИШИНА, Юлия Михайловна; ШАНГИНА, Ольга Анатольевна; КАМЕНЕВА, Евгения Александровна.
The prevalence of resistant nosocomial infections in the intensive care unit of a versatile hospital.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 140, n. 1, p. 48-52, apr. 2018.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/206>. Date accessed: 28 jan. 2026.
Issue
Section
Lifestyle, ecology
