An analysis of the gas composition of exhaled air in the differential diagnosis of chronic tonsillitis
Abstract
Background: determine differences in gas composition of exhaled breath in patients with chronic tonsillitis of compensated and decompensated forms using the array of metal oxide gas sensors. Methods: 105 patients with chronic tonsillitis and 27 patients without inflammatory diseases of the upper respiratory tract. Samples of exhaled air were analyzed using the apparatus «Multisens-5» (E-nose). Result: It was shown significant difference (p<0.05) in the structure of the volatile organic compounds of the exhaled air among patients with chronic tonsillitis of compensated and decompensated forms. Conclusion: Multi-sensor analysis is applicable for differential diagnosis of chronic tonsillitis due to its rapid, simple, and noninvasive nature.
References
1. Вакс В.Л., Домрачева Е.Г., Собакинская Е.А., Черняева М.Б. Анализ выдыхаемого воздуха: физические методы, приборы и медицинская диагностика // Успехи физических наук. – 2014. – Т. 184. № 7. – С. 739-758.
2. Заболотный Д.И., Мельников О.Ф., Кищук В.В. Клинико-иммунологические основы классификации хронического тонзиллита // Журнал ушных, носовых и горловых болезней. – 2003. - №5. – С. 44-48.
3. Мельников О.Ф. Иммунологические аспекты генеза хронического тонзиллита и регуляции функциональной активности миндалин: автореф. дис. ... д-ра мед. наук. – Киев, 1981. – 41 с.
4. Новиков Д.К., Новиков П.Д. Клиническая иммунопатология: руководство. – М.: Медицинская литература, 2009. – 464 с.
5. Пальчун В.Т., Лучихин Л.А., Крюков А.И. Воспалительные заболевания глотки. – М.: ГЭОТАР-Медиа, 2007. – 288 с.
6. Пальчун В.Т., Полякова Т.С., Романова О.Н. Лечебно-диагностические подходы к проблеме хронического тонзиллита // Вестник оториноларингологии. – 2001. - №1. – С. 4-7.
7. Плужников М.С., Лавренова Г.В., Левин М.Я. и др. Хронический тонзиллит: клиника и иммунологические аспекты – СПб.: Диалог, 2010. – 224 с.
8. Солдатов И.Б. Хронический тонзиллит и другие очаги инфекции верхних дыхательных путей // 7 съезд оториноларингологов СССР: тезисы докладов. – М., 1975. – С. 60-66.
9. Степанов Е.В. Методы высокочувствительного газового анализа молекул-биомаркеров в исследованиях выдыхаемого воздуха // Труды ИОФАН. – 2005. – Т. 61. – С. 5-47.
10. D'Amico A., Di Natale C., Falconi C., et al. Detection and identification of cancers by the electronic nose // Expert. Opin. Med. Diagn. – 2012. – Vol. 6(3). – P. 175-185.
11. Fens N., van der Schee M.P., Brinkman P., et al. Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions. // Clin. Exp. Allergy. – 2013. – Vol. 43(7). –P. 705-715.
12. Fens N., Roldaan A.C., van der Schee M.P., et al. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease // Clin. Exp. Allergy. – 2011. – Vol. 41 (10). – P. 1371-1378.
13. Wilson A.D. Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath // Metabolites. – 2015. – Vol. 5(1). – P. 140-163.
REFERENCES
1. Vaks V.L., Domracheva Е.G., Sobakinskaya Е.А., Chernyaeva M.B. Analysis of exhaled air: physical methods, devices and medical diagnostics // Uspehi fizicheskih nauk. – 2014. – V. 184. № 7. – P. 739-758. (in Russian)
2. Zabolotniy D.I., Melnikov О. F., Kischyuk V.V. Clinical and immunological basis of classification of chronic tonsillitis // Zhurnal ushnikh, nosovikh I gorlovikh bolezney. – 2003. - №5. – P. 44-48. (in Russian)
3. Melnikov О.F. Immunological aspects of the genesis of chronic tonsillitis and regulation of the functional activity of the tonsils: Thesis DSc in Medicine. – Kiev, 1981. – 41 p. (in Russian)
4. Novikov D.К., Novikov P.D. Clinical immunopathology: Manual. – Мoscow: Меditsinskaya literatura, 2009. – 464 p. (in Russian)
5. Palchun V.Т., Luchihin L.А., Kryukov А.I. Inflammatory diseases of the throat. – Мoscow: GEOTAR-Меdiа, 2007. – 288 p. (in Russian)
6. Palchun V.Т., Polyakova Т.S., Romanova О.N. Therapeutic and diagnostic approaches to the problem of chronic tonsillitis // Vestnik othorhingologii. – 2001. -№1. – P. 4-7. (in Russian)
7. Pluzhnikov М.S. Lavrenova G.V., Levin М.Y., et al. Chronic tonsillitis: clinical and immunological aspects. – St. Petersburg: Dialog, 2005. – 222 p. (in Russian)
8. Soldatov I.B. Chronic tonsillitis and other foci of infection of the upper respiratory tract // 7-th Congress of otorhinolaryngology USSR: Abstracts. – Мoscow, 1975. –P. 60-66. (in Russian)
9. Stepanov Е.V. Methods of highly sensitive gas analysis molecular biomarkers in studies of exhaled air // Trudi IOFAN. – 2005. – V. 61. – P. 5-47. (in Russian)
10. D'Amico A., Di Natale C., Falconi C., et al. Detection and identification of cancers by the electronic nose // Expert. Opin. Med. Diagn. – 2012. – Vol. 6(3). – P. 175-185.
11. Fens N., van der Schee M.P., Brinkman P., et al. Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions. // Clin. Exp. Allergy. – 2013. – Vol. 43(7). –P. 705-715.
12. Fens N., Roldaan A.C., van der Schee M.P., et al. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease // Clin. Exp. Allergy. – 2011. – Vol. 41 (10). – P. 1371-1378.
13. Wilson A.D. Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath // Metabolites. – 2015. – Vol. 5(1). – P. 140-163.
2. Заболотный Д.И., Мельников О.Ф., Кищук В.В. Клинико-иммунологические основы классификации хронического тонзиллита // Журнал ушных, носовых и горловых болезней. – 2003. - №5. – С. 44-48.
3. Мельников О.Ф. Иммунологические аспекты генеза хронического тонзиллита и регуляции функциональной активности миндалин: автореф. дис. ... д-ра мед. наук. – Киев, 1981. – 41 с.
4. Новиков Д.К., Новиков П.Д. Клиническая иммунопатология: руководство. – М.: Медицинская литература, 2009. – 464 с.
5. Пальчун В.Т., Лучихин Л.А., Крюков А.И. Воспалительные заболевания глотки. – М.: ГЭОТАР-Медиа, 2007. – 288 с.
6. Пальчун В.Т., Полякова Т.С., Романова О.Н. Лечебно-диагностические подходы к проблеме хронического тонзиллита // Вестник оториноларингологии. – 2001. - №1. – С. 4-7.
7. Плужников М.С., Лавренова Г.В., Левин М.Я. и др. Хронический тонзиллит: клиника и иммунологические аспекты – СПб.: Диалог, 2010. – 224 с.
8. Солдатов И.Б. Хронический тонзиллит и другие очаги инфекции верхних дыхательных путей // 7 съезд оториноларингологов СССР: тезисы докладов. – М., 1975. – С. 60-66.
9. Степанов Е.В. Методы высокочувствительного газового анализа молекул-биомаркеров в исследованиях выдыхаемого воздуха // Труды ИОФАН. – 2005. – Т. 61. – С. 5-47.
10. D'Amico A., Di Natale C., Falconi C., et al. Detection and identification of cancers by the electronic nose // Expert. Opin. Med. Diagn. – 2012. – Vol. 6(3). – P. 175-185.
11. Fens N., van der Schee M.P., Brinkman P., et al. Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions. // Clin. Exp. Allergy. – 2013. – Vol. 43(7). –P. 705-715.
12. Fens N., Roldaan A.C., van der Schee M.P., et al. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease // Clin. Exp. Allergy. – 2011. – Vol. 41 (10). – P. 1371-1378.
13. Wilson A.D. Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath // Metabolites. – 2015. – Vol. 5(1). – P. 140-163.
REFERENCES
1. Vaks V.L., Domracheva Е.G., Sobakinskaya Е.А., Chernyaeva M.B. Analysis of exhaled air: physical methods, devices and medical diagnostics // Uspehi fizicheskih nauk. – 2014. – V. 184. № 7. – P. 739-758. (in Russian)
2. Zabolotniy D.I., Melnikov О. F., Kischyuk V.V. Clinical and immunological basis of classification of chronic tonsillitis // Zhurnal ushnikh, nosovikh I gorlovikh bolezney. – 2003. - №5. – P. 44-48. (in Russian)
3. Melnikov О.F. Immunological aspects of the genesis of chronic tonsillitis and regulation of the functional activity of the tonsils: Thesis DSc in Medicine. – Kiev, 1981. – 41 p. (in Russian)
4. Novikov D.К., Novikov P.D. Clinical immunopathology: Manual. – Мoscow: Меditsinskaya literatura, 2009. – 464 p. (in Russian)
5. Palchun V.Т., Luchihin L.А., Kryukov А.I. Inflammatory diseases of the throat. – Мoscow: GEOTAR-Меdiа, 2007. – 288 p. (in Russian)
6. Palchun V.Т., Polyakova Т.S., Romanova О.N. Therapeutic and diagnostic approaches to the problem of chronic tonsillitis // Vestnik othorhingologii. – 2001. -№1. – P. 4-7. (in Russian)
7. Pluzhnikov М.S. Lavrenova G.V., Levin М.Y., et al. Chronic tonsillitis: clinical and immunological aspects. – St. Petersburg: Dialog, 2005. – 222 p. (in Russian)
8. Soldatov I.B. Chronic tonsillitis and other foci of infection of the upper respiratory tract // 7-th Congress of otorhinolaryngology USSR: Abstracts. – Мoscow, 1975. –P. 60-66. (in Russian)
9. Stepanov Е.V. Methods of highly sensitive gas analysis molecular biomarkers in studies of exhaled air // Trudi IOFAN. – 2005. – V. 61. – P. 5-47. (in Russian)
10. D'Amico A., Di Natale C., Falconi C., et al. Detection and identification of cancers by the electronic nose // Expert. Opin. Med. Diagn. – 2012. – Vol. 6(3). – P. 175-185.
11. Fens N., van der Schee M.P., Brinkman P., et al. Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions. // Clin. Exp. Allergy. – 2013. – Vol. 43(7). –P. 705-715.
12. Fens N., Roldaan A.C., van der Schee M.P., et al. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease // Clin. Exp. Allergy. – 2011. – Vol. 41 (10). – P. 1371-1378.
13. Wilson A.D. Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath // Metabolites. – 2015. – Vol. 5(1). – P. 140-163.
Published
2018-04-16
How to Cite
НАЧАРОВ, Петр Васильевич; ДЖАГАЦПАНЯН, Игорь Эдуардович; КОРНЕЕНКОВ, Алексей Александрович.
An analysis of the gas composition of exhaled air in the differential diagnosis of chronic tonsillitis.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 139, n. 8, p. 12-15, apr. 2018.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/213>. Date accessed: 28 jan. 2026.
Issue
Section
Original research
