BACTEROIDES FRAGILIS В РАЗВИТИИ АБДОМИНАЛЬНОЙ ХИРУРГИЧЕСКОЙ ИНФЕКЦИИ

  • Татьяна Владимировна Фадеева Иркутский научный центр хирургии и травматологии; Иркутский государственный медицинский университет http://orcid.org/0000-0002-4681-905X
  • Наталья Николаевна Дрёмина Иркутский научный центр хирургии и травматологии; Иркутский государственный медицинский университет http://orcid.org/0000-0002-2540-4525
  • Ирина Александровна Шурыгина Иркутский научный центр хирургии и травматологии; Иркутский государственный медицинский университет http://orcid.org/0000-0003-3980-050X
  • Елена Евгеньевна Чепурных Иркутский научный центр хирургии и травматологии; Иркутский государственный медицинский университет http://orcid.org/0000-0002-3197-4276

Аннотация

Представлен обзор отечественной, зарубежной литературы и собственные исследования о роли B. fragilis в развитии абдоминальных гнойно-септических заболеваний и их послеоперационных осложнений (перитонита, внутрибрюшных абсцессов, инфицированного панкреонекроза, аппендицита и др.), которой, по современным представлениям, принадлежит одно из ведущих мест в хирургической инфекционной патологии человека. Проанализирована и обобщена информация об основных факторах патогенности и вирулентности токсигенных и нетоксигенных B. fragilis на фенотипическом, молекулярно-генетическом уровне, необходимых для выживания бактероида в патофизиологических условиях, уровне их антибиотикорезистентности. Обсуждена роль аэротолерантности B. fragilis и комплекса кислородно-детоксикационных ферментативных и неферментативных систем антиокислительной защиты в условиях окислительного стресса (каталазы, супероксид-дисмутазы, фумарат-редуктазы, тиоредоксин-зависимой пероксидазы, алкилгидропероксид-редуктазы, гемм-ферритина и др.). Представлены новые данные об известных (капсульные полисахариды, протеазы, нейраминидазы, гепариназа, гиалуронидаза, фибринолизин, энтеротоксин фрагилизин BFT – B. fragilis toxin и т.д.) и менее изученных уникальных факторах вирулентности (металлопротеиназы  BFT и IIMPII (BfPAI), протеаза бактероида fragipain Fpn, фибриноген-связывающий протеин BF-FBP, гемолизины (hlyA, hlyB, hlyC, hlyD, hlyE, hlyF, hlyG и hlyIII, HlyBA), а также наиболее вероятном способе секреции и доставки во внеклеточное пространство вырабатываемых токсинов и ферментов B. fragilis с помощью наружных везикул. Обращено внимание на повышение устойчивости B.fragilis к современным противомикробным препаратам, что необходимо учитывать при выборе адекватной антимикробной терапии.

Литература

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23. Houston S., Blakely G., McDowell A., et al. Binding anddegradation of fibrinogen by Bacteroides fragilis and characterization of a 54 kDa fibrinogen-binding protein // Microbiol. 2010. №156. P.2516–2526. DOI: 10.1099/mic.0.038588-0.
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29. Liu C.H., Lee S.M., Vanlare J.M., et al. Regulation of surface architecture by symbiotic bacteria mediates host colonization // Proc Natl Acad Sci USA. 2008. Vol.105. №10 P.3951–3956. DOI: 10.1073/pnas.0709266105.
30. Lobo L.A., Benjamim C.F., Oliveira A.C. The interplay between microbiota and inflammation: lessons from peritonitis and sepsis // Clinical & Translational. Immunology. 2016. №5 P.90. DOI:10.1038/cti.2016.32.
31. Lobo L.A., Jenkins A.L., Jeffrey S. C., Rocha E.R. Expression of Bacteroides fragilis hemolysins in vivo and role of HlyBA in an intra-abdominal infection model // Microbiologyopen. 2013. Vol. 2 №2. P.326–337. DOI: 10.1002/mbo3.76
32. Mazmanian S.K., Liu C.H., Tzianabos A.O., Kasper D.L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system // Cell. 2005. Vol. 122. P.107–118.
33. Meehan B.M., Malamy M. H. Fumarate reductase is a major contributor to the generation of reactive oxygen species in the anaerobe Bacteroides fragilis // Microbiology. 2012. Vol. 158. P.539–546. DOI:10.1099/mic.0.054403-0.
34. Montravers P., Lepape A., Dubreuil L., et al. Clinical and microbiological profiles of community-acquired and nosocomial intra-abdominal infections: results of the French prospective, observational EBIIA study // The Journal of antimicrobial chemotherapy. 2009. Vol.63. №4. P.85-94. DOI: 10.1093/jac/dkp005.
35. Ngo J.T., Parkins M.D., Gregson D.B., et al. Population-based assessment of the incidence, risk factors, and outcomes of anaerobic bloodstream infections // Infection. 2013. Vol. 41. №1. P.41–48. DOI: 10.1007/s15010-012-0389-4.
36. O'Donoghue EJ, Krachler AM. Mechanisms of outer membrane vesicle entry into host cells // Cell Microbiol. 2016. Vol. 18. №11. P.1508–1517. DOI: 10.1111/cmi.12655.
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Опубликована
2019-01-31
Как цитировать
ФАДЕЕВА, Татьяна Владимировна et al. BACTEROIDES FRAGILIS В РАЗВИТИИ АБДОМИНАЛЬНОЙ ХИРУРГИЧЕСКОЙ ИНФЕКЦИИ. Сибирский медицинский журнал (Иркутск) 16+, [S.l.], v. 154, n. 3, p. 5-11, янв. 2019. ISSN 1815-7572. Доступно на: <http://smj.ismu.baikal.ru/index.php/osn/article/view/301>. Дата доступа: 20 авг. 2019
Раздел
Научные обзоры