DYNAMICS OF LIPID METABOLISM INDICATORS IN CARDIAC TISSUE UNDER EXPERIMENTAL ADRENALINE DAMAGE AND CELL THERAPY CONDITIONS
Abstract
The article presents data on the effect of xenogenic heart cell transplantation on the dynamics of lipid metabolism in rat cardiac tissue under conditions of experimental adrenaline stress (lasting for twenty-four hours). During transplantation, a cholesterol decrease in cardiac tissue was more active than control, which was apparently due to the breakdown of lipoproteins into triglycerides and further into free fatty acids. Active reduction of cholesterol and low molecular weight proteins, obviously, occurred due to their use for the synthesis of regulatory compounds and adaptive proteins, and possibly due to the cost of restoring cellular structures. Transplantation also contributed to the active entry of energy substrates into cardiac tissue, their aerobic and anaerobic synthesis in the tissue itself, which created more favorable conditions for metabolic processes.
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2. Богородская С.Л., Клинова С.Н., Гутник И.Н., Пивоваров Ю.И., Курильская Т.Е., Рунович А.А. Оценка энергетических показателей миокарда при моделировании адреналинового повреждения в условиях клеточной трансплантации // Клеточные технологии в биологии и медицине. 2009. № 3. С. 154–156.
3. Богородская С.Л., Клинова С.Н., Микашова М.Б., Голубев С.С., Пивоваров Ю.И., Курильская Т.Е., Рунович А.А. Трансплантация ксеногенных кардиомиоцитов при экспериментальном адреналиновом повреждении миокарда: Ферментативная активность и морфологические параметры // Клеточные технологии в биологии и медицине. 2008. № 3. С. 132–135.
4. Искра А.И., Лепехова С.А. Перспектива использования биотехнологий для коррекции печеночной недостаточности (Обзор литературы) // Acta Biomedica Scientifica. 2014. Т. 95. № 1. С. 112–119.
5. Рунович А.А., Пивоваров Ю.И., Курильская Т.Е., Богородская С.Л., Бадуев Б.К., Галеев Ю.М., Кузнецова Э.Э., Корякина Л.Б., Сергеева А.С. Атеросклероз и клеточная терапия / Под редакцией А.А. Руновича, Ю.И. Пивоварова, Т.Е. Курильской. Иркутск, 2005. 304 с.
6. Рунович А.А., Бадуев Б.К., Богородская С.Л., Боровский Г.Б., Сергеева А.С. Влияние ксеногенных неонатальных кардиомиоцитов на индукцию белков теплового шока при катехоламиновом повреждении миокарда в эксперименте // Современные наукоемкие технологии. 2004. № 3. С. 150–151.
7. Chen K.-H., Cheng Ch.-H., Wallace Ch.G., Yuen Ch.-M., Kao G.-Sh., Chen Y.-L., Shao P.-L., Chen Y.-L., Chai H.-T., Lin K.-Ch., Liu Ch.-F., Chang H.-W., Lee M.S., Yip H.-K. Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke // Oncotarget. 2016. Vol. 7 (46). P. 74537–74556.
8. Golpanian S., Wolf A., Hatzistergos K.E., Hare J.M. Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue // Physiol. Rev. 2016. Vol. 96 (3). P. 1127–1168.
9. Wang Z., Dong N., Niu Y., Zhang Z., Zhang C., Liu V., Zhou T., Wu Q., Cheng K. Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction // J. Cell. Mol. Med. 2017. Vol. 21 (10). P. 2432–2440.
10. Zhu H.-T., Yu L., Lyu Y., Wang B. Optimal pig donor selection in islet xenotransplantation: current status and future perspectives // J. Zhejiang. Univ. Sci. B. 2014. Vol. 15 (8). P. 681–691.
REFERENCES
1. Bogorodskaya S.L., Klinova S.N., Golubev S.S., Zaritskaya L.V., Batunova E.V., Ezhikeeva S.D., Ten M.N., Kurilskaya T.E., Pivovarov Yu.I. ATPase activity and levels of ions in cardiac tissue in experimental adrenalin injury and cell transplantation // Sibirskij medicinskij zurnal (Irkutsk). 2010. Vol. 97 (6). P. 158–160. (in Russian)
2. Bogorodskaya S.L., Klinova S.N., Gutnik I.N., Pivovarov Yu.I., Kurilskaya T.E., Runovich A.A. Evaluation of myocardial energy indices in the simulation of adrenaline damage in cell transplantation // Kletochnye tekhnologii v biologii i meditsine. 2009. № 3. P. 154–156. (in Russian)
3. Bogorodskaya S.L., Klinova S.N., Mikashova M.B., Golubev S.S., Pivovarov Yu.I., Kurilskaya T.E., Runovich A.A. Transplantation of xenogenic cardiomyocytes with experimental adrenaline myocardial damage: Enzymatic activity and morphological parameters // Kletochnye tekhnologii v biologii i meditsine. 2008. № 3. P. 132–135. (in Russian)
4. Iskra A.I., Lepekhova S.A. The prospect of using biotechnology for the correction of liver failure (literature review) // Acta Biomedica Scientifica. 2014. Vol. 95 (1). P. 112–119. (in Russian)
5. Runovich A.A., Pivovarov Yu.I., Kurilskaya T.E., Bogorodskaya S.L., Baduev B.K., Galeev Yu.M., Kuznetsova E.E., Koryakina L.B., Sergeeva A.S. Atherosclerosis and cell therapy / Edited by A.A. Runovich, Yu.I. Pivovarov, T.E. Kurilskaya. Irkutsk, 2005. 304 p. (in Russian)
6. Runovich A.A., Baduev B.K., Bogorodskaya S.L., Borovsky G.B., Sergeeva A.S. Influence of xenogenic neonatal cardiomyocytes on the induction of heat shock proteins in catecholamine myocardial damage in the experiment // Sovremennye naukoemkie tekhnologii. 2004. № 3. P. 150–151. (in Russian)
7. Chen K.-H., Cheng Ch.-H., Wallace Ch.G., Yuen Ch.-M., Kao G.-Sh., Chen Y.-L., Shao P.-L., Chen Y.-L., Chai H.-T., Lin K.-Ch., Liu Ch.-F., Chang H.-W., Lee M.S., Yip H.-K. Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke // Oncotarget. 2016. Vol. 7 (46). P. 74537–74556.
8. Golpanian S., Wolf A., Hatzistergos K.E., Hare J.M. Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue // Physiol. Rev. 2016. Vol. 96 (3). P. 1127–1168.
9. Wang Z., Dong N., Niu Y., Zhang Z., Zhang C., Liu V., Zhou T., Wu Q., Cheng K. Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction // J. Cell. Mol. Med. 2017. Vol. 21 (10). P. 2432–2440.
10. Zhu H.-T., Yu L., Lyu Y., Wang B. Optimal pig donor selection in islet xenotransplantation: current status and future perspectives // J. Zhejiang. Univ. Sci. B. 2014. Vol. 15 (8). P. 681–691.
Published
2019-02-01
How to Cite
БОГОРОДСКАЯ, Светлана Леонидовна; КУРИЛЬСКАЯ, Татьяна Ефимовна; РУНОВИЧ, Алексей Анатольевич.
DYNAMICS OF LIPID METABOLISM INDICATORS IN CARDIAC TISSUE UNDER EXPERIMENTAL ADRENALINE DAMAGE AND CELL THERAPY CONDITIONS.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 154, n. 3, p. 43-47, feb. 2019.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/309>. Date accessed: 05 july 2026.
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Original research
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