The natural course of chronic hepatitis C in women of fertile age.
Abstract
Aim: to assess the impact of chronic hepatitis C in young women on fertility.
Methods. A comprehensive examination and comparison of 71 patients with chronic hepatitis C (HCV) with the results of 32 healthy women of reproductive age on the basis of the infectious Department of 5 EKG of the Russian Federation (Yekaterinburg) in 2017-2018.d.
Results. the interpretation of the results showed that women with HCV infection, compared with healthy women, are more likely to be diagnosed infertility, healthy women were mostly in the same marriage, the presence of children and their total number was significantly higher. In women with HCV infection were significantly more likely to re-register the marriage and infertility. The predominance of T cells in absolute numbers and in percentage terms (at the expense of T-helper cells and T-activated lymphocytes) were detected in patients with CHC, in healthy individuals was dominated by B-cells.
Conclusion. the Natural course of HCV infection in women of fertile age is characterized by laboratory changes, mainly at the stage of F3-F4, moderate cytolytic syndrome, a decrease in the level of vitamin D. the data that the basis of chronic HCV infection is directly a defect of T-cell response are Confirmed. Early diagnosis and timely treatment of HCV will prevent the violation of female reproductive function.
References
1. Жданов К.В., Лобзин Ю.В., Гусев Д.А., Козлов К.В. Вирусные гепатиты. СПб.: Фолиант, 2011. 82 с.
2. Жданов К.В., Козлов К.В., Загородников Г.Г. и др. Организация диспансерного динамического наблюдения за военнослужащими с хроническими вирусными инфекционными заболеваниями // Вестник академии военных наук. 2014. № 3. С. 121-125.
3. Кузнецов С.Д., Макашова В.В., Тутельян А.В., Шабалина С.В. Взаимосвязь генетических факторов вируса и больного при хроническом гепатите С // Инфекционные болезни. 2015. Т. 13. № 3. С. 30-36.
4. Морозов В.Г., Тихомолова Е.Г., Малов С.И. и др. Риск развития гепатоцеллюлярной карциномы у больных с хроническим гепатитом с после противовирусной терапии препаратами прямого противовирусного действия: собственные наблюдения // Инфекционные болезни. 2018. Т. 16. № 4. С. 38-47. DOI: 10.20953/1729-9225-2018-4-38-47
5. ООН итоговый отчет «Репродуктивное здоровье России 2011».
6. Патлусов Е.П., Чернов В.С., Юлчурин Р.К. Морфологический и клинико-биохимический ответ на стандартную противовирусную терапию у больных хроническим гепатитом С. // Медицинский вестник Башкортостана. 2018. Т. 13. № 6. С. 5-11.
7. Федоров Б.А., Колесникова Л.И., Сутурина Л.В. Состояние гормонально-метаболического гомеостаза у женщин репродуктивного возраста с вирусным гепатитом В и С // Фундаментальные исследования. 2011. №2. С. 157-160.
8. Burra P. Liver abnormalities and endocrine diseases // Best. Pract. Res. Clin. Gastroenterol. 2013. Vol. 27 (4). Р. 553-563. DOI: 10.1016/j.bpg.2013.06.014.
9. Karampatou A., Han X., Kondili L.A., at al. Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV // Journal of Hepatology. 2017. Vol. 67. P. pii: S0168-8278(17)32259-6. DOI: 10.1016/j.jhep.2017.08.019.
10. Mitchell S., Bungay V., Day C.A. Has the Experience of Hepatitis C Diagnosis Improved Over the Last Decade? An Analysis of Canadian Women's Experiences // Can. J. Nurs. Res. 2016. Vol. 48 (1). Р. 21-28. DOI: 10.1177/0844562116665477.
11. Mohd Hanafiah K., Groeger J., Flaxman A.D., Wiersma S.T. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence // Hepatology. 2013. Vol. 57. Р. 1333–1342. DOI: 10.1002/hep.26141.
12. Rallon N.I., Soriano V., Benito J.M. Adaptive cell immune response against the hepatitis C virus infection. // Med. Clin. 2007. Vol. 129 (12). P. 469-476.
13. World health organization guidelines for the screening, care and treatment of persons with chronic hepatitis C infection. Geneva: Switzerland, 2016. 138 р.
14. Zuure F.R., Urbanus A.T., Langendam M.W. Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review // BMC Public. Health. 2014. Vol. 14. P. 66. DOI: 10.1186/1471-2458-14-66.
REFERENCES
1. Zhdanov K.V., Lobzin Yu.V., Gusev D.A., Kozlov K.V. Viral hepatitis. St. Petersburg: Foliant, 2011. 82 p. (in Russian)
2. Zhdanov K.V., Kozlov K.V., Zagorodnikov G.G., et al. Organization of follow-up dynamic monitoring of military personnel with chronic viral infectious diseases // Vestnik akademii voyennykh nauk. 2014. No. 3. P. 121-125. (in Russian)
3. Kuznetsov S.D., Makashova V.V., Tutelyan A.V., Shabalina S.V. The relationship of genetic factors of the virus and the patient with chronic hepatitis C // Infektsionnyye bolezni. 2015. Vol. 13. No. 3. P. 30-36. (in Russian)
4. Morozov V.G., Tikhomolova E.G., Malov S.I., et al. Risk of hepatocellular carcinoma in patients with chronic hepatitis С after antiviral therapy with direct antiviral agents: own observations // Infektsionnyye bolezni. 2018. Vol. 16. № 4. P. 38-47. DOI: 10.20953/1729-9225-2018-4-38-47
5. UN final report "Reproductive Health of Russia 2011". (in Russian)
6. Patlusov E.P., Chernov V.S., Yulchurin R.K. Morphological and clinical-biochemical response to standard antiviral therapy in patients with chronic hepatitis C. // Meditsinskiy vestnik Bashkortostana. 2018. Vol. 13. No. 6. P. 5-11. (in Russian)
7. Fedorov B.A., Kolesnikova L.I., Suturina L.V. The state of hormonal and metabolic homeostasis in women of reproductive age with viral hepatitis B and C // Fundamental'nyye issledovaniya. 2011. №2. P. 157-160. (in Russian)
8. Burra P. Liver abnormalities and endocrine diseases // Best. Pract. Res. Clin. Gastroenterol. 2013. Vol. 27 (4). Р. 553-563. DOI: 10.1016/j.bpg.2013.06.014.
9. Karampatou A., Han X., Kondili L.A., at al. Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV // Journal of Hepatology. 2017. Vol. 67. P. pii: S0168-8278(17)32259-6. DOI: 10.1016/j.jhep.2017.08.019.
10. Mitchell S., Bungay V., Day C.A. Has the Experience of Hepatitis C Diagnosis Improved Over the Last Decade? An Analysis of Canadian Women's Experiences // Can. J. Nurs. Res. 2016. Vol. 48 (1). Р. 21-28. DOI: 10.1177/0844562116665477.
11. Mohd Hanafiah K., Groeger J., Flaxman A.D., Wiersma S.T. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence // Hepatology. 2013. Vol. 57. Р. 1333–1342. DOI: 10.1002/hep.26141.
12. Rallon N.I., Soriano V., Benito J.M. Adaptive cell immune response against the hepatitis C virus infection. // Med. Clin. 2007. Vol. 129 (12). P. 469-476.
13. World health organization guidelines for the screening, care and treatment of persons with chronic hepatitis C infection. Geneva: Switzerland, 2016. 138 р.
14. Zuure F.R., Urbanus A.T., Langendam M.W. Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review // BMC Public. Health. 2014. Vol. 14. P. 66. DOI: 10.1186/1471-2458-14-66.
2. Жданов К.В., Козлов К.В., Загородников Г.Г. и др. Организация диспансерного динамического наблюдения за военнослужащими с хроническими вирусными инфекционными заболеваниями // Вестник академии военных наук. 2014. № 3. С. 121-125.
3. Кузнецов С.Д., Макашова В.В., Тутельян А.В., Шабалина С.В. Взаимосвязь генетических факторов вируса и больного при хроническом гепатите С // Инфекционные болезни. 2015. Т. 13. № 3. С. 30-36.
4. Морозов В.Г., Тихомолова Е.Г., Малов С.И. и др. Риск развития гепатоцеллюлярной карциномы у больных с хроническим гепатитом с после противовирусной терапии препаратами прямого противовирусного действия: собственные наблюдения // Инфекционные болезни. 2018. Т. 16. № 4. С. 38-47. DOI: 10.20953/1729-9225-2018-4-38-47
5. ООН итоговый отчет «Репродуктивное здоровье России 2011».
6. Патлусов Е.П., Чернов В.С., Юлчурин Р.К. Морфологический и клинико-биохимический ответ на стандартную противовирусную терапию у больных хроническим гепатитом С. // Медицинский вестник Башкортостана. 2018. Т. 13. № 6. С. 5-11.
7. Федоров Б.А., Колесникова Л.И., Сутурина Л.В. Состояние гормонально-метаболического гомеостаза у женщин репродуктивного возраста с вирусным гепатитом В и С // Фундаментальные исследования. 2011. №2. С. 157-160.
8. Burra P. Liver abnormalities and endocrine diseases // Best. Pract. Res. Clin. Gastroenterol. 2013. Vol. 27 (4). Р. 553-563. DOI: 10.1016/j.bpg.2013.06.014.
9. Karampatou A., Han X., Kondili L.A., at al. Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV // Journal of Hepatology. 2017. Vol. 67. P. pii: S0168-8278(17)32259-6. DOI: 10.1016/j.jhep.2017.08.019.
10. Mitchell S., Bungay V., Day C.A. Has the Experience of Hepatitis C Diagnosis Improved Over the Last Decade? An Analysis of Canadian Women's Experiences // Can. J. Nurs. Res. 2016. Vol. 48 (1). Р. 21-28. DOI: 10.1177/0844562116665477.
11. Mohd Hanafiah K., Groeger J., Flaxman A.D., Wiersma S.T. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence // Hepatology. 2013. Vol. 57. Р. 1333–1342. DOI: 10.1002/hep.26141.
12. Rallon N.I., Soriano V., Benito J.M. Adaptive cell immune response against the hepatitis C virus infection. // Med. Clin. 2007. Vol. 129 (12). P. 469-476.
13. World health organization guidelines for the screening, care and treatment of persons with chronic hepatitis C infection. Geneva: Switzerland, 2016. 138 р.
14. Zuure F.R., Urbanus A.T., Langendam M.W. Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review // BMC Public. Health. 2014. Vol. 14. P. 66. DOI: 10.1186/1471-2458-14-66.
REFERENCES
1. Zhdanov K.V., Lobzin Yu.V., Gusev D.A., Kozlov K.V. Viral hepatitis. St. Petersburg: Foliant, 2011. 82 p. (in Russian)
2. Zhdanov K.V., Kozlov K.V., Zagorodnikov G.G., et al. Organization of follow-up dynamic monitoring of military personnel with chronic viral infectious diseases // Vestnik akademii voyennykh nauk. 2014. No. 3. P. 121-125. (in Russian)
3. Kuznetsov S.D., Makashova V.V., Tutelyan A.V., Shabalina S.V. The relationship of genetic factors of the virus and the patient with chronic hepatitis C // Infektsionnyye bolezni. 2015. Vol. 13. No. 3. P. 30-36. (in Russian)
4. Morozov V.G., Tikhomolova E.G., Malov S.I., et al. Risk of hepatocellular carcinoma in patients with chronic hepatitis С after antiviral therapy with direct antiviral agents: own observations // Infektsionnyye bolezni. 2018. Vol. 16. № 4. P. 38-47. DOI: 10.20953/1729-9225-2018-4-38-47
5. UN final report "Reproductive Health of Russia 2011". (in Russian)
6. Patlusov E.P., Chernov V.S., Yulchurin R.K. Morphological and clinical-biochemical response to standard antiviral therapy in patients with chronic hepatitis C. // Meditsinskiy vestnik Bashkortostana. 2018. Vol. 13. No. 6. P. 5-11. (in Russian)
7. Fedorov B.A., Kolesnikova L.I., Suturina L.V. The state of hormonal and metabolic homeostasis in women of reproductive age with viral hepatitis B and C // Fundamental'nyye issledovaniya. 2011. №2. P. 157-160. (in Russian)
8. Burra P. Liver abnormalities and endocrine diseases // Best. Pract. Res. Clin. Gastroenterol. 2013. Vol. 27 (4). Р. 553-563. DOI: 10.1016/j.bpg.2013.06.014.
9. Karampatou A., Han X., Kondili L.A., at al. Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV // Journal of Hepatology. 2017. Vol. 67. P. pii: S0168-8278(17)32259-6. DOI: 10.1016/j.jhep.2017.08.019.
10. Mitchell S., Bungay V., Day C.A. Has the Experience of Hepatitis C Diagnosis Improved Over the Last Decade? An Analysis of Canadian Women's Experiences // Can. J. Nurs. Res. 2016. Vol. 48 (1). Р. 21-28. DOI: 10.1177/0844562116665477.
11. Mohd Hanafiah K., Groeger J., Flaxman A.D., Wiersma S.T. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence // Hepatology. 2013. Vol. 57. Р. 1333–1342. DOI: 10.1002/hep.26141.
12. Rallon N.I., Soriano V., Benito J.M. Adaptive cell immune response against the hepatitis C virus infection. // Med. Clin. 2007. Vol. 129 (12). P. 469-476.
13. World health organization guidelines for the screening, care and treatment of persons with chronic hepatitis C infection. Geneva: Switzerland, 2016. 138 р.
14. Zuure F.R., Urbanus A.T., Langendam M.W. Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review // BMC Public. Health. 2014. Vol. 14. P. 66. DOI: 10.1186/1471-2458-14-66.
Published
2019-07-26
How to Cite
ПАТЛУСОВ, Евгений Павлович; ЧЕРНОВ, Вячеслав Сергеевич; ТИМИРХАНОВА, Ольга Михайловна.
The natural course of chronic hepatitis C in women of fertile age..
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 157, n. 2, p. 23-26, july 2019.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/316>. Date accessed: 01 jan. 2026.
Issue
Section
Original research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
