Features of the content of proinflammatory cytokines in umbilical cord blood in full-term infants with hypoxic events.
Abstract
Aim: to evaluate the immunological indices of umbilical cord blood in newborns who underwent intrauterine hypoxia and / or birth asphyxia.
Methods. The study included 134 full-term newborns, which in the course of the study were divided into 2 groups: Group 1 (n = 81) – children who underwent intrauterine hypoxia and / or birth asphyxia; Group 2 (n = 51) – the control group, children born with a normal Apgar score and who did not experience intrauterine hypoxia. The method of solid-phase enzyme immunoassay conducted a study of the level of interleukins in umbilical cord blood in full-term newborns who underwent intrauterine hypoxia and / or asphyxia during labor.
Results. Markers of transferred hypoxic events (in comparison with the control group) were increased levels of such pro-inflammatory cytokines as interleukin (IL) -1β (41.20 pg / ml ± 84.97), IL-6 (97.27 pg / ml ± 158, 64), IL-8 (118.81 pg / ml ± 147.95).
Conclusion. Increased levels of IL-1β, IL-6, IL-8 in cord blood in children with hypoxic events can be used as a marker for the occurrence of ischemic brain damage, which in the future will make it possible to predict possible outcomes and develop a number of recommendations for reducing the negative hypoxic effects on health full-term newborns.
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REFERENCES
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11. Murray K.N., Parry-Jones A.R., Allan S.M. Interleukin-1 and acute brain injury. // Front Cell Neurosci. 2015. Vol. 6(9). P. 18.
12. Placha K., Luptakova D., Baciak L., Ujhazy E., Juranek I. Neonatal brain injury as a consequence of insufficient cerebral oxygenation. // Neuro Endocrinol. 2016. Vol. 37(2). P. 79–961.
2. Иутинский Э.М., Дворянский С.А., Дрождина М.Б. Течение беременности и родов у женщин с фетоплацентарной недостаточностью. // Научные ведомости Белгородского государственного университета. Серия Медицина. Фармация. 2014. № 18. С. 54-57.
3. Князева А.С., Страмбовская Н.Н., Терешков П.П. Концентрация интерлейкинов в плазме крови больных хронической ишемией головного мозга, носителей генетического полиморфизма некоторых противовоспалительных цитокинов // Молекулярная медицина. 2015. № 6. С. 48-52.
4. Перлман Д.M. Неврология. Проблемы и противоречия в неонатологии. / Под ред. Р.А. Полина. М.: Логосфера, 2015. 392 с.
5. Чистякова Г.Н., Ремизова Л.Л., Газиева Л.А., Бычкова С.В., Занина Е.В., Чарипова Б.Т. Про- и противовоспалительные медиаторы у новорожденных с перинатальной патологией. // Российский вестник перинатологии и педиатрии. 2014. Т. 59. №2. С. 66–70.
6. Якорнова Г.В., Ремизова И.И., Чистякова Г.Н., Устъянцева Л.С. Динамика провоспалительных цитокинов у детей, родившихся у женщин с осложненной беременностью, в зависимости от течения раннего периода адаптации. // Российский вестник перинатологии и педиатрии. 2015. Т. 60. №4. С. 50–56.
7. Хаитов Р.М. Иммунология. Структура и функции иммунной системы: Учебное пособие. М.: ГЭОТАР-Медиа, 2014. 280 с.
8. Chaparro-Huerta V., Flores-Soto M.E., Merin Sigala M.E., et al. Proinflammatory cytokines, enolase and S-100 as early biochemical indicators of hypoxic-ischemic encephalopathy following perinatal asphyxia in newborns. // Pediatr Neonatol. 2017. Vol. 58(1). P. 70-76.
9. Doll D.N., Barr T.L., Simpkins J.W. Cytokines: their role in stroke and potential use as biomarkers and therapeutic targets. // Aging Dis. 2014. Vol. 5(5). P. 294–306.
10. Massaro A.N., Wu Y.W., Bammler T.K., Comstock B., et al. Plasma biomarkers of brain injury in neonatal hypoxic-ischemic encephalopathy. // J Pediatr. 2018. Vol. 194. P. 67-75.
11. Murray K.N., Parry-Jones A.R., Allan S.M. Interleukin-1 and acute brain injury. // Front Cell Neurosci. 2015. Vol. 6(9). P. 18.
12. Placha K., Luptakova D., Baciak L., Ujhazy E., Juranek I. Neonatal brain injury as a consequence of insufficient cerebral oxygenation. // Neuro Endocrinol. 2016. Vol. 37(2). P. 79–961.
REFERENCES
1. Gryaznova M.A., Khamnueva L.Yu., Davydova A.V., Orlova G.M. Glomerular filtration rate and interleukin 8 level in patients with Graves' disease. // Clinical and experimental thyroidology. 2013. Vol. 9(4). P. 46-51. (in Russian)
2. Iutinskij Eh.M., Dvoryanskij S.A., Drozhdina M.B. The course of pregnancy and childbirth in women with fetoplacental insufficiency. // Nauchnyye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya Meditsina. Farmatsiya.. 2014. No 18. P. 54-57. (in Russian)
3. Knyazeva A.S., Strambovskaya N.N., Tereshkov P.P. Concentration of interleukines in blood plasma in patients with chronic cerebral ischemia – carriers of anti-inflammatory cytokines genes polymorphisms // Molekulyarnaya meditsina. 2015. № 6. P. 48-52. (in Russian)
4. Perlman D.M. Neurology: Neonatology Questions and Controversies. / Ed. R.A. Polin. Moscow: Logosfera, 2015. 392 p. (in Russian)
5. Chistyakova G.N., Remizova L.L., Gazieva L.A., Bychkova S.V., Zanina E.V., Charipova B.T. Pro- and anti-inflammatory mediators in neonates with perinatal pathology. // Russian journal of Perinatology and Pediatrics. 2014. Vol. 59 (2). P. 66–70. (in Russian)
6. Yаkornova G.V., Remizova I.I., Chistiakova G.N., Ustieiantseva L.S. Time course of changes in proinflammatory cytokines in infants born to women with complicated pregnancy in relation to the course of an early adaptation period. // Russian journal of Perinatology and Pediatrics. 2015. Vol. 60 (4). P. 50–56. (in Russian)
7. Haitov R.M. Immunology. Structure and functions of the immune system. Textbook. Moscow: GEOTAR-Media, 2014. 280 p. (in Russian)
8. Chaparro-Huerta V., Flores-Soto M.E., Merin Sigala M.E., et al. Proinflammatory cytokines, enolase and S-100 as early biochemical indicators of hypoxic-ischemic encephalopathy following perinatal asphyxia in newborns. // Pediatr Neonatol. 2017. Vol. 58(1). P. 70-76.
9. Doll D.N., Barr T.L., Simpkins J.W. Cytokines: their role in stroke and potential use as biomarkers and therapeutic targets. // Aging Dis. 2014. Vol. 5(5). P. 294–306.
10. Massaro A.N., Wu Y.W., Bammler T.K., Comstock B., et al. Plasma biomarkers of brain injury in neonatal hypoxic-ischemic encephalopathy. // J Pediatr. 2018. Vol. 194. P. 67-75.
11. Murray K.N., Parry-Jones A.R., Allan S.M. Interleukin-1 and acute brain injury. // Front Cell Neurosci. 2015. Vol. 6(9). P. 18.
12. Placha K., Luptakova D., Baciak L., Ujhazy E., Juranek I. Neonatal brain injury as a consequence of insufficient cerebral oxygenation. // Neuro Endocrinol. 2016. Vol. 37(2). P. 79–961.
Published
2019-07-30
How to Cite
ПАНЧЕНКО, Александра Сергеевна; ПАНОВА, Марина Сергеевна.
Features of the content of proinflammatory cytokines in umbilical cord blood in full-term infants with hypoxic events..
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 157, n. 2, p. 35-37, july 2019.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/346>. Date accessed: 01 jan. 2026.
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