ADDITIONAL METHODS OF TREATMENT FOR UROTELIAL DAMAGES

  • Владимир Анатольевич Воробьев Irkutsk State Medical University, Irkutsk, Russian Federation; Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation http://orcid.org/0000-0003-3285-5559
  • Владимир Анатольевич Белобородов 1Irkutsk State Medical University, Irkutsk, Russian Federation; Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation http://orcid.org/0000-0002-3299-1924
  • Сергей Леонидович Попов Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation http://orcid.org/0000-0002-1073-7896
  • Юлия Каирбековна Павлюк Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation
  • Наталья Михайловна Титова Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation http://orcid.org/0000-0002-0451-3482
  • Андрей Юрьевич Ветохин Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation http://orcid.org/0000-0002-6008-2197
  • Татьяна Викторовна Спиридович Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

Abstract

In the process of literature review, the authors searched for scientific articles in the following databases: Scopus, PubMed. The aim of the study was to review the literature data on the problems of additional methods of treatment that can improve the results of urothelium healing. Wound healing is a complex process of replacing dead tissue in the body with viable. The duration of each phase of the healing of the urethral plate is increased by a longer period compared with the skin. The typical ideal dressing material removes exudate, creates a moist environment, protects against foreign matter and promotes tissue regeneration. However, in some cases, the use of auxiliary therapeutic methods and drugs to optimize the regeneration process is required. The process of wound healing involves a complex interaction of several factors to replace damaged tissue. Clinicians are looking for better solutions to increase the effectiveness of wound healing. The basic principle underlying hyperbaric oxygenation (HBO) is to increase the concentration of dissolved oxygen in the blood when it is fed under atmospheric pressure, and can be used to stimulate vasculogenesis and tissue regeneration. Various drugs applied to a postoperative wound, including using physiotherapeutic methods, can significantly affect wound healing and reduce the likelihood of gross scar growth in the postoperative period. In the future, research may be conducted to produce new materials that can restore the integrity of the urothelium within a few days and with minimal complications. 

Author Biographies

Владимир Анатольевич Воробьев, Irkutsk State Medical University, Irkutsk, Russian Federation; Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

 Vorobev Vladimir Anatolyevich – PhD, Assistant Professor, Department of General Surgery and Anesthesiology, Irkutsk State Medical University; SPIN-code: 9896-6243, ORCID:0000-0003-3285-5559,Address: 664003, Irkutsk, Krasnogo Vosstaniya str, 1, e-mail: terdenecer@gmail.com

Владимир Анатольевич Белобородов, 1Irkutsk State Medical University, Irkutsk, Russian Federation; Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

Beloborodov Vladimir Anatolyevich – MD, Professor, Head of the Department of General Surgery and Anesthesiology, Irkutsk State Medical University; SPIN-code: 5116-0931, ORCID:0000-0002-3299-1924,Address: 664003, Irkutsk, KrasnogoVosstaniya str., 1, tel. +7 (3952) 243825, e-mail: bva555@yandex.ru

Сергей Леонидович Попов, Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

Popov Sergey Leomidovich – PhD, head of the department of urology, Irkutsk Municipal Clinical Hospital №1; Address: 664046, Irkutsk, Baikalskaya str., 118, tel. 7 (3952) 229959; e-mail: uro.igkb1@gmail.com

Юлия Каирбековна Павлюк, Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

 Pavlyuk Julia Kairbekovna – head of the department of hyperbaric oxygenation, Irkutsk Municipal Clinical Hospital №1, SPIN-code: 3937-8145,ORCID: 0000-0002-7880-4197, Address: 664046, Irkutsk, Baikalskaya str., 118, e-mail: y_pavluyk@mail.ru

Наталья Михайловна Титова, Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

Titova Natalya Michaylovna – doctor of the department of hyperbaric oxygenation, Irkutsk Municipal Clinical Hospital No. 1, SPIN-code: 7105-1350,ORCID: 0000-0002-0451-3482, Address: 664046, Irkutsk, Baikalskaya str., 118, e-mail: titova.1959@bk.ru4

Андрей Юрьевич Ветохин, Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

 Vetokhin Andrey Yuryevich – head of the department of physiotherapy, Irkutsk Municipal Clinical Hospital №1, SPIN-code: 9213-8985, ORCID: 0000-0002-6008-2197, Address: 664046, Irkutsk, Baikalskaya str., 118, tel. 7 (3952) 703769; email: andr-vetokhin@yandex.ru

Татьяна Викторовна Спиридович, Irkutsk Municipal Clinical Hospital №1, Irkutsk, Russian Federation

Spiridovich Tatiana Viktorovna – physiotherapist, Irkutsk Municipal Clinical Hospital №1, SPIN-code: 1453-3815, ORCID: 0000-0002-2839-1202, Address: 664046, Irkutsk, Baikalskaya str., 118, tel. 7 (3952) 703769; e-mail: t.spiridovich@yandex.ru.

References

ЛИТЕРАТУРА – REFERENCES
1. Abrão J., Fernandes C.R., White P.F., et al. Effect of local anaesthetic infiltration with bupivacaine and ropivacaine on wound healing: a placebo-controlled study // International Wound Journal. 2014. Vol. 11. №4. P.379-385. DOI: 10.1111/j.1742481X.2012.01101.x.
2. Anheuser P., Mühlstädt S., Kranz J., et al. Significance of Hyperbaric Oxygenation in the Treatment of Fournier’s Gangrene: A Comparative Study // Urologia Internationalis. 2018. Vol. 101. №4. P.467-471. DOI: 10.1159/000493898.
3. Bedair H., Liu T.T., Kaar J.L., et al. Matrix metalloproteinase-1 therapy improves muscle healing // Journal of Applied Physiology (Bethesda, Md.: 1985). 2007. Vol. 102. №6. P.2338-2345.
4. Boateng J.S., Matthews K.H., Stevens H.N., et al. Wound healing dressings and drug delivery systems: a review // Journal of Pharmaceutical Sciences. 2008. Vol. 97. №8. P.2892-2923.
5. Buckley C.J., Cooper J.S. Hyperbaric, Angiogenesis Treasure Island (FL): StatPearls Publishing, 2019. URL: http://www.ncbi. nlm.nih.gov/books/NBK482485.
6. Bush N., Snodgrass W. Hyperbaric Oxygen Therapy Improves Oral Graft Take In Hypospadias Stag Reoperations // The Journal of Urology. 2019. 101097JU0000000000000145. DOI:10.1097/ JU.0000000000000145.
7. Capelli-Schellpfeffer M., Gerber G.S. The use of hyperbaric oxygen in urology // The Journal of Urology. 1999. Vol. 162. №3.Pt 1. P.647-654.
8. Chong V., Rice M. The effectiveness of hyperbaric oxygen therapy (HBOT) in radiation-induced haemorrhagic cystitis // The New Zealand Medical Journal. 2016. Vol. 129. №1446. P.79-83.
9. Eggleton P., Bishop A.J., Smerdon G.R. Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence // Chronic Wound Care Management and Research. 2015. Vol. 2015. №2. P.81-93. DOI: 10.2147/CWCMR. S60319.
10. Funahashi Y., Yoshida M., Yamamoto T., et al. Intravesical application of rebamipide promotes urothelial healing in a rat cystitis model // The Journal of Urology. 2014. Vol. 192. №6. P.1864-1870. DOI: 10.1016/j.juro.2014.06.081.
11. Gandhi J., Seyam O., Smith N.L., et al. Clinical utility of hyperbaric oxygen therapy in genitourinary medicine // Medical Gas Research. 2018. Vol. 8. №1. P.29-33. DOI: 10.4103/20459912.229601.
12. Gassner H.G., Brissett A.E., Otley C.C., et al. Botulinum toxin to improve facial wound healing: A prospective, blinded, placebo-controlled study // Mayo Clinic Proceedings. 2006. Vol. 81. №8. P.1023-1028.
13. Gomez-Iturriaga A., Crook J., Evans W., et al. The efficacy of hyperbaric oxygen therapy in the treatment of medically refractory soft tissue necrosis after penile brachytherapy // Brachytherapy. 2011. Vol. 10. №6. P.491-497. DOI: 10.1016/j.brachy.2011.01.009.
14. Hadanny A., Lang E., Copel L., et al. Hyperbaric oxygen can induce angiogenesis and recover erectile function // International Journal of Impotence Research. 2018. Vol. 30. №6. P.292-299. DOI: 10.1038/s41443-018-0023-9.
15. Hancı V., Hakimoğlu S., Özaçmak H., et al. Comparison of the effects of bupivacaine, lidocaine, and tramadol infiltration on wound healing in rats // Revista Brasileira De Anestesiologia. 2012. Vol. 62. №6. P.799-810. DOI: 10.1016/S0034-7094(12)70180-0.
16. Kahle A.C., Cooper J.S. Hyperbaric Physiological And Pharmacological Effects Gases Treasure Island (FL): StatPearls Publishing, 2019.URL: Available from http://www.ncbi.nlm.nih. gov/books/NBK470481.
17. Levi-Schaffer F., Nagler A., Slavin S., et al. Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone // The Journal of Investigative Dermatology. 1996. Vol. 106. №1. P.84-88.
18. Lim S.W., Wang C.C., Wang Y.H., et al. Microglial activation induced by traumatic brain injury is suppressed by postinjury treatment with hyperbaric oxygen therapy // The Journal of Surgical Research. 2013. Vol. 184. №2. P.1076-1084. DOI:10.1016/j.jss.2013.04.070.
19. Logadottir Y., Delbro D., Fall M., et al. Cytokine expression in patients with bladder pain syndrome/interstitial cystitis ESSIC type 3C // The Journal of Urology. 2014. Vol. 192. №5. P.15641568. DOI: 10.1016/j.juro.2014.04.099.
20. Oliai C., Fisher B., Jani A., et al. Hyperbaric oxygen therapy for radiation-induced cystitis and proctitis // International Journal of Radiation Oncology, Biology, Physics. 2012. Vol. 84. №3. P.733740. DOI: 10.1016/j.ijrobp.2011.12.056.
21. Ophoven A., Rossbach G., Oberpenning F., et al. Hyperbaric oxygen for the treatment of interstitial cystitis: long-term results of a prospective pilot study // European Urology. 2004. Vol. 46. №1. P.108-113.
22. Pasquier D., Hoelscher T., Schmutz J., et al. Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review // Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. 2004. Vol. 72. №1. P.1-13.
23. Pedersen T.O., Xing Z., Finne-Wistrand A., et al. Hyperbaric oxygen stimulates vascularization and bone formation in rat calvarial defects // International Journal of Oral and Maxillofacial Surgery. 2013. Vol. 42. №7. P.907-914. DOI: 10.1016/j. ijom.2013.01.003.
24. Sahin M.O., Sen V., Eser E., et al. The Effect of Hyperbaric Oxygen Therapy on Erectile Functions: A Prospective Clinical Study // Urologia Internationalis. 2018. Vol. 101. №2. P.206-211. DOI: 10.1159/000490356.
25. Sahinkanat T., Ozkan K.U., Ciralik H., et al.Botulinum toxin-A to improve urethral wound healing: an experimental study in a rat model // Urology. 2009. Vol. 73. №2. P.405-409. DOI: 10.1016/j.urology.2008.07.051.
26. Sen V., Sahin M.O., Irer B., et al. The impact of hyperbaric oxygen therapy on erectile functions and serum testosterone levels in patients with erectile dysfunction // The Aging Male. 2019. P.15. DOI:10.1080/13685538.2019.1578740.
27. Tanaka T., Minami A., Uchida J., et al. Potential of hyperbaric oxygen in urological diseases // International Journal of Urology. 2019. DOI: 10.1111/iju.14015.
Published
2019-12-07
How to Cite
ВОРОБЬЕВ, Владимир Анатольевич et al. ADDITIONAL METHODS OF TREATMENT FOR UROTELIAL DAMAGES. Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 157, n. 2, p. 13-16, dec. 2019. ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/371>. Date accessed: 01 jan. 2026.
Citation Formats
Issue
Vol 157 No 2 (2019)
Section
Scientific reviews
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.