CORRECTION METHODS OF LIPID PEROXIDATION ACTIVITY IN THE THYROID DISFUNCTION
Abstract
In experiments on adult outbred white male rats, the influence of iodine-containing thyroid hormones on the lipid peroxidation activity in the liver under emotional stress and methods of targeted correction of excessive lipoperoxidation were introduced by introducing like small L-thyroxine doses (1.5-3.0 μg /kg for 28 days) or an extract of pupae of oak silkworm (7 μg free amino acids / 100 g of weight for 12 weeks).
References
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REFERENCES
1. Bondarenko O.N., Bondarenko N.A., Manukhina E.B. Effects of different stress techniques and adaptation on behavioral and somatic indices in rats // Bulletin of Experimental Biology and Medicine. – 1999. – Vol. 128. № 2. – P. 794-796.
2. Vladimirov Yu.A. Peroxide oxidation of lipids in biological membranes. – Moscow: Nauka, 1972. – 252 p. (in Russian)
3. Gorodetskaya I.V., Gusakova E.A. Mechanisms of limitation of lysosomal dysfunction under stress by the iodine-containing thyroid hormones // Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. – 2014. – Vol. 46. №2. – P. 37–41. (in Russian)
4. Gorodetskaya I.V., Gusakova E.A., Evdokimova O.V. Peripheral mechanisms of the stress-protective effect of iodinecontaining thyroid hormones // Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta. – 2016. – Vol. 15. № 6. – P. 41–53. (in Russian)
5. Zhukov V.I., Tkachenko A.S. Lipid peroxidation system and activity of apoptiosis in experimental chronic gastroenterocolitis // Nauchnyye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya – 2013. – Vol. 23. №18. – P. 138–142. (in Russian)
6. Zapadnyuk I.P., et al. Laboratory animals. Breeding content, use in experiment. – Kiev: Visha school, 1983. – P. 197-218. (in Russian)
7. Lelevich V.V. Biological chemistry. – Grodno: State Mining and Metallurgical University, 2009. – 256 p.
8. Orekhovich V.N. Modern methods in biochemistry. – Moscow: Medicine, 1977. – 392 p. (in Russian)
9. Binder C.J. Lipid modification and lipid peroxidation products in innate immunity and inflammation Biochimica et Biophysica Acta (BBA) // Mol Cell Biol Lipids. – 2017. – Vol. 1862, № 4. – P. 369–370.
10. Boltze C., et al. Radiation–induced thyroid carcinogenesis as a function of time and dietary iodine supply: an in vivo model of tumorigenesis in the rat // Endocrinology. − 2002. − Vol. 143. № 7. − P. 2584−2592.
11. Demer L., Tintut Y. The roles of lipid oxidation products and receptor activator of nuclear Factor-kappa B signaling in atherosclerotic calcification // Circ Res. – 2011. – Vol. 108. № 12. – Р. 1482–1493.
12. Kaemmerer E., et al. Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis / // Investigative Ophthalmology & Visual Science. – 2007. – Vol. 48. № 3. – Р. 1342–1347.
13. Choi1 S.W., et al. Lipid peroxidation product, 4-HNE (4-Hydroxynonenal) Modulates hERG channels // The FASEB Journal. – 2015. – Vol. 29. № 1. – P. 104–108.
2. Владимиров Ю.А. Перекисное окисление липидов в биологических мембранах – М.: Наука, 1972 – 252 с.
3. Городецкая И.В., Гусакова Е.А. Механизмы ограничения йодсодержащими тиреоидными гормонами лизосомальной дисфункции при стрессе // Журнал Гродненского государственного медицинского университета. – 2014. – Т. 46. №2. – С. 37–41.
4. Городецкая И.В., Гусакова Е.А., Евдокимова О.В. Периферические механизмы стресс-протекторного эффекта йодсодержащих гормонов щитовидной железы // Вестник Витебского государственного медицинского университета. – 2016. – Т. 15. № 6. – С. 41–53.
5. Жуков В.И., Ткаченко А.С. Система перекисного окисления липидов и активность апоптоза при экспериментальном хроническом гастроэнтероколите // Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. – 2013. – Т. 23. №18. – C. 138–142.
6. Западнюк И.П. и др. Лабораторные животные. Разведение содержание, использование в эксперименте. – Киев: Виша школа, 1983. – С.197–218.
7. Лелевич В.В. Биологическая химия. – Гродно: ГрГМУ, 2009. – 256 с.
8. Орехович В.Н. Современные методы в биохимии. – М.: Медицина, 1977. – 392 с.
9. Binder C.J. Lipid modification and lipid peroxidation products in innate immunity and inflammation Biochimica et Biophysica Acta (BBA) // Mol Cell Biol Lipids. – 2017. – Vol. 1862, № 4. – P. 369–370.
10. Boltze C., et al. Radiation–induced thyroid carcinogenesis as a function of time and dietary iodine supply: an in vivo model of tumorigenesis in the rat // Endocrinology. − 2002. − Vol. 143. № 7. − P. 2584−2592.
11. Demer L., Tintut Y. The roles of lipid oxidation products and receptor activator of nuclear Factor-kappa B signaling in atherosclerotic calcification // Circ Res. – 2011. – Vol. 108. № 12. – Р. 1482–1493.
12. Kaemmerer E., et al. Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis / // Investigative Ophthalmology & Visual Science. – 2007. – Vol. 48. № 3. – Р. 1342–1347.
13. Choi1 S.W., et al. Lipid peroxidation product, 4-HNE (4-Hydroxynonenal) Modulates hERG channels // The FASEB Journal. – 2015. – Vol. 29. № 1. – P. 104–108.
REFERENCES
1. Bondarenko O.N., Bondarenko N.A., Manukhina E.B. Effects of different stress techniques and adaptation on behavioral and somatic indices in rats // Bulletin of Experimental Biology and Medicine. – 1999. – Vol. 128. № 2. – P. 794-796.
2. Vladimirov Yu.A. Peroxide oxidation of lipids in biological membranes. – Moscow: Nauka, 1972. – 252 p. (in Russian)
3. Gorodetskaya I.V., Gusakova E.A. Mechanisms of limitation of lysosomal dysfunction under stress by the iodine-containing thyroid hormones // Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. – 2014. – Vol. 46. №2. – P. 37–41. (in Russian)
4. Gorodetskaya I.V., Gusakova E.A., Evdokimova O.V. Peripheral mechanisms of the stress-protective effect of iodinecontaining thyroid hormones // Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta. – 2016. – Vol. 15. № 6. – P. 41–53. (in Russian)
5. Zhukov V.I., Tkachenko A.S. Lipid peroxidation system and activity of apoptiosis in experimental chronic gastroenterocolitis // Nauchnyye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya – 2013. – Vol. 23. №18. – P. 138–142. (in Russian)
6. Zapadnyuk I.P., et al. Laboratory animals. Breeding content, use in experiment. – Kiev: Visha school, 1983. – P. 197-218. (in Russian)
7. Lelevich V.V. Biological chemistry. – Grodno: State Mining and Metallurgical University, 2009. – 256 p.
8. Orekhovich V.N. Modern methods in biochemistry. – Moscow: Medicine, 1977. – 392 p. (in Russian)
9. Binder C.J. Lipid modification and lipid peroxidation products in innate immunity and inflammation Biochimica et Biophysica Acta (BBA) // Mol Cell Biol Lipids. – 2017. – Vol. 1862, № 4. – P. 369–370.
10. Boltze C., et al. Radiation–induced thyroid carcinogenesis as a function of time and dietary iodine supply: an in vivo model of tumorigenesis in the rat // Endocrinology. − 2002. − Vol. 143. № 7. − P. 2584−2592.
11. Demer L., Tintut Y. The roles of lipid oxidation products and receptor activator of nuclear Factor-kappa B signaling in atherosclerotic calcification // Circ Res. – 2011. – Vol. 108. № 12. – Р. 1482–1493.
12. Kaemmerer E., et al. Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis / // Investigative Ophthalmology & Visual Science. – 2007. – Vol. 48. № 3. – Р. 1342–1347.
13. Choi1 S.W., et al. Lipid peroxidation product, 4-HNE (4-Hydroxynonenal) Modulates hERG channels // The FASEB Journal. – 2015. – Vol. 29. № 1. – P. 104–108.
Published
2017-11-14
How to Cite
БАЛАЕВА-ТИХОМИРОВА, Ольга Михайловна; ГУСАКОВА, Елена Анатольевна.
CORRECTION METHODS OF LIPID PEROXIDATION ACTIVITY IN THE THYROID DISFUNCTION.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 149, n. 2, p. 20-23, nov. 2017.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/4>. Date accessed: 13 oct. 2026.
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Section
Original research
