Применение методов генетического тестирования в спорте
Аннотация
Исследование для определения частоты встречаемости генотипа полиморфизма C34T AMPD1 гена для оценки физической активности у 20 узбекских спортсменов, занимающихся футболом. Полиморфизм гена AMPD1, который участвует в энергетическом обеспечении мышечной активности и метаболизма, был проанализирован среди узбекских спортсменов и контрольной группы. Основываясь на сравнении распределения генотипов и скоростей аллелей гена AMPD1, был обнаружен генотип CC ассоциации генов AMPD1 с предрасположенностью к высокой физической работоспособности и выносливости.
Литература
1. Rundell K.W., Tullson P.C., Terjung R.L. Altered kinetics of AMP deaminase by myosin binding. // Am. J. Physiology. – 1992. – Vol. 263. – P. 294-299.
2. Fischer S., Drenckhahn C., Wolf C., et al. Clinical significance and neuropathology of primary MADD in C34-T and G468-T mutations of the AMPD1 gene. // Clin. Neuropathol. – 2005. – Vol. 24 (2). – P. 77-85.
3. Norman B., Sabina R.L., Jansson E. Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint-exercise in asymptomatic subjects. // J. Appl. Physiol. – 2001. – Vol. 91. – P. 258-264.
4. Norman B., Mahnke-Zizelman D.K., Vallis A., Sabina A. Genetic and other determinants of AMP deaminase activity in healthy adult skeletal muscle. // J. Appl. Physiol. – 1998. – Vol. 85. – P. 1273–1278.
5. Rico-Sanz J., Rankinen T., Joanisse D.R., et al. HERITAGE Family study: Associations between cardiorespiratory responses to exercise and the C34T AMPD1 gene polymorphism in the HERITAGE Family Study. // Physiol. Genomics. – 2003. – Vol. 14. – P. 161-166
6. Rubio J.C., Martin M.A., Rabadan M., et al. Frequency of the C34T mutation of the AMPD1 gene in world-class endurance athletes: does this mutation impair performance? // J. Appl. Physiol. – 2005. – Vol. 98 (6). – P. 2108-2112.
7. Binkley P.F, Auseon A., Cooke G. A polymorphism of the gene encoding AMPD1: clinical impact and proposed mechanisms in congestive heart failure. // Congest Heart Fail. – 2004. – Vol. 10. – P. 274–278.
8. Safranow K., Suchy J., Jakubowska K., et al. AMPD1 gene mutations are associated with obesity and diabetes in Polish patients with cardiovascular diseases. // J Appl Genet. – 2011. – Vol. 52. – P. 67–76.
9. Toyama K., Morisaki H., Kitamura Y., et al. Haplotype analysis of human AMPD1 gene: origin of common mutant allele. // J Med Genet. – 2004. – Vol. 41 (6). – P. 74.
10. Loh E., Rebbeck T.R., Mahoney P.D., et al. Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure. // Circulation. – 1999. – Vol. 99. – P. 1422–1425.
11. Anderson J.L., Habashi J., Carlquist J.F., et al. A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery disease. // J Am Coll Cardiol. – 2000. – Vol. 36. – P. 1248–1252.
12. Gastmann A., Sigusch H.H., Henke A., et al. Role of adenosine monophosphate deaminase-1 gene polymorphism in patients with congestive heart failure (influence on tumor necrosis factor-alpha level and outcome) // Am J Cardiol. – 2004. – Vol. 93. – P. 1260–1264.
13. Yazaki Y., Muhlestein J.B., Carlquist J.F., et al. A common variant of the AMPD1 gene predicts improved survival in patients with ischemic left ventricular dysfunction. // J Card Fail. – 2008. – Vol. 10. – P. 316–320.
14. Agewall S., Norman B. Association between AMPD1 gene polymorphism and coagulation factors in patients with coronary heart disease. // Pathophysiol Haemost Thromb. – 2006. – Vol. 35. – P. 440–444.
15. Collins R.P., Palmer B.R., Pilbrow A.P., et al. Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients. // Am Heart J. – 2006. – Vol. 152. – P. 312–320.
16. de Groote P., Lamblin N., Helbecque N., et al. The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients. // Am Heart J. – 2006. – Vol. 152. – P. 736–741
17. Andreassi M.G., Botto N., Laghi-Pasini F., et al. AMPD1 (C34T) polymorphism and clinical outcomes in patients undergoing myocardial revascularization. // Int J Cardiol. – 2005. – Vol. 101. – P. 191–195
18. Fischer H., Esbjornsson M., Sabina R.L., et al. AMP deaminase deficiency is associated with lower sprint cycling performance in healthy subjects. // J Appl Physiol. – 2007. – Vol. 103. – P. 315–322.
2. Fischer S., Drenckhahn C., Wolf C., et al. Clinical significance and neuropathology of primary MADD in C34-T and G468-T mutations of the AMPD1 gene. // Clin. Neuropathol. – 2005. – Vol. 24 (2). – P. 77-85.
3. Norman B., Sabina R.L., Jansson E. Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint-exercise in asymptomatic subjects. // J. Appl. Physiol. – 2001. – Vol. 91. – P. 258-264.
4. Norman B., Mahnke-Zizelman D.K., Vallis A., Sabina A. Genetic and other determinants of AMP deaminase activity in healthy adult skeletal muscle. // J. Appl. Physiol. – 1998. – Vol. 85. – P. 1273–1278.
5. Rico-Sanz J., Rankinen T., Joanisse D.R., et al. HERITAGE Family study: Associations between cardiorespiratory responses to exercise and the C34T AMPD1 gene polymorphism in the HERITAGE Family Study. // Physiol. Genomics. – 2003. – Vol. 14. – P. 161-166
6. Rubio J.C., Martin M.A., Rabadan M., et al. Frequency of the C34T mutation of the AMPD1 gene in world-class endurance athletes: does this mutation impair performance? // J. Appl. Physiol. – 2005. – Vol. 98 (6). – P. 2108-2112.
7. Binkley P.F, Auseon A., Cooke G. A polymorphism of the gene encoding AMPD1: clinical impact and proposed mechanisms in congestive heart failure. // Congest Heart Fail. – 2004. – Vol. 10. – P. 274–278.
8. Safranow K., Suchy J., Jakubowska K., et al. AMPD1 gene mutations are associated with obesity and diabetes in Polish patients with cardiovascular diseases. // J Appl Genet. – 2011. – Vol. 52. – P. 67–76.
9. Toyama K., Morisaki H., Kitamura Y., et al. Haplotype analysis of human AMPD1 gene: origin of common mutant allele. // J Med Genet. – 2004. – Vol. 41 (6). – P. 74.
10. Loh E., Rebbeck T.R., Mahoney P.D., et al. Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure. // Circulation. – 1999. – Vol. 99. – P. 1422–1425.
11. Anderson J.L., Habashi J., Carlquist J.F., et al. A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery disease. // J Am Coll Cardiol. – 2000. – Vol. 36. – P. 1248–1252.
12. Gastmann A., Sigusch H.H., Henke A., et al. Role of adenosine monophosphate deaminase-1 gene polymorphism in patients with congestive heart failure (influence on tumor necrosis factor-alpha level and outcome) // Am J Cardiol. – 2004. – Vol. 93. – P. 1260–1264.
13. Yazaki Y., Muhlestein J.B., Carlquist J.F., et al. A common variant of the AMPD1 gene predicts improved survival in patients with ischemic left ventricular dysfunction. // J Card Fail. – 2008. – Vol. 10. – P. 316–320.
14. Agewall S., Norman B. Association between AMPD1 gene polymorphism and coagulation factors in patients with coronary heart disease. // Pathophysiol Haemost Thromb. – 2006. – Vol. 35. – P. 440–444.
15. Collins R.P., Palmer B.R., Pilbrow A.P., et al. Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients. // Am Heart J. – 2006. – Vol. 152. – P. 312–320.
16. de Groote P., Lamblin N., Helbecque N., et al. The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients. // Am Heart J. – 2006. – Vol. 152. – P. 736–741
17. Andreassi M.G., Botto N., Laghi-Pasini F., et al. AMPD1 (C34T) polymorphism and clinical outcomes in patients undergoing myocardial revascularization. // Int J Cardiol. – 2005. – Vol. 101. – P. 191–195
18. Fischer H., Esbjornsson M., Sabina R.L., et al. AMP deaminase deficiency is associated with lower sprint cycling performance in healthy subjects. // J Appl Physiol. – 2007. – Vol. 103. – P. 315–322.
Опубликована
2018-03-24
Как цитировать
ЯКУБОВ, Миракбар Даниярович.
Применение методов генетического тестирования в спорте.
Сибирский медицинский журнал (Иркутск) 16+, [S.l.], v. 149, n. 2, p. 34-36, март 2018.
ISSN 1815-7572. Доступно на: <http://smj.ismu.baikal.ru/index.php/osn/article/view/50>. Дата доступа: 09 янв. 2025
Выпуск
Раздел
Образ жизни, экология
