The effectiveness of the use of multimodal anesthesia in patientsoperated for neoplasms of lung
Abstract
We examined and treated 74 patients (59 men and 15 women) aged from 46 to 60 years with malignant neoplasms of the lung. 42 patients were operated on under multimodal anesthesia with epidural blockade, and 32 patients- under inhalation and intravenous anesthesia with artificial lung ventilation. In the preoperative, intraoperative and earlypostoperative period in blood plasma the concentration of adrenaline, noradrenaline, dophamine, cortisol, insulin andglucose, and parameters of acid-base composition in arterial blood were studied. Found that the most important pathogenicfactor that causes stress reactions in patients operated for malignant neoplasms of lungs in the conditions of stationaryof pain relief, is a marked activation of sympathoadrenal system. This is manifested by metabolic disorders, nociceptionand oxygen balance in the body. The operations performed in the multimodal anesthesia, showed minimum change in thebasic parameters of homeostasis, were short-term, compensated and reversible. Pain syndrome after operation and in earlypostoperative period was absent or less expressed.
References
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REFERENCES
1. Gorobets E.S, Karmanov I.E., Buydenok Yu.V. Epidural blockade as a component of anesthesia in oncologic surgeries of the lung. // Regionarnaya anesteziya i lechenie boli: Materialy Vserossiiskoi conferentsii. – Tver, 2004. – P. 134-140. (in Russian)
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3. Kachur S.V., Kachur A.K., Dolgikh V.T., Solovyev A.O. Assessment of hemodynamic profile in the intraoperative period in patients operated on for lung tumors in a multimodal anesthesia // Sibirskij Medicinskij Zurnal (Irkutsk). – 2015. - №3. – P. 67-69. (in Russian)
4. Kozlov A.I., Kozlova M.A. Cortizol as a marker of stress: overview // Physiologia cheloveka. – 2014. – Vol. 40. № 2. – Р. 123-136. (in Russian)
5. Lyuboshevsky P.A., Ovechkin A.M. Opportunities for evolution and correction of surgical stress response with operatic high trauma // Regionarnaya anesteziya i lechenie boli. – 2014. – Vol. 8. №4. – P. 5-21. (in Russian)
6. Day Y.J. Anesthesia, analgesia and surgical stress // Acta Anaesthesiol. Taiwan. – 2014. – Vol. 52, № 2. – P. 47-48.
7. Hubner M., Mantziari S., Demartines N., et al. Postoperative albumin drop is a marker for surgical stress and a predictor for clinical outcome: a pilot study // Gastroenterol. Res Pract. – 2016. – Vol. 4. № 6. – P. 87-95.
8. Ilies C., Gruenewald M., Ludwigs J., et al. Evaluation of the surgical stress index during spinal and general anaesthesia // Br. J. Anaesth. – 2010. – Vol. 105. №4. – P. 533-537.
9. Ladron de Guevara H.D., Fumaro F.L., Yevenes S.A., Miguel J. Positron emission tomography/computed tomography for lung cancer staging // Rev. Med. Chil. – 2015. – Vol. 143, № 1. – P. 22-29.
10. Schwartz R.M., Yip R., Olkin I., et al. Impact of surgery for stage IA non-small-cell lung cancer on patient quality of life // J. Communiti Support Oncol. – 2016. – Vol. 14, №1. – P. 37-44.
11. Stewart B.W., Wild C.P. Word Cancer Report. – Geneva, 2014. – 630 p.
12. Torre L.A., Siegel R.L., Jemal A. Lung Cancer Statistics // Adv. Exp. Med. Biol. – 2016. – Vol. 893. – P. 1-19.
2. Груздев В.Е., Горобец Е.С. Мультимодальная комбинированная анестезия как способ анестезиологического обеспечения операций на легких у больных с низкими функциональными резервами дыхания // Регионарная анестезия и лечение боли. – 2013. – Т. 7, № 3. – С. 26-30.
3. Качур С.В., Качур А.К., Долгих В.Т., Соловьев А.О. Оценка гемодинамического профиля в интраоперационном периоде у пациентов, оперированных в условиях мультимодальной анестезии по поводу новообразований легких // Сибирский медицинский журнал (Иркутск). – 2015. - №3. – С. 67-69.
4. Козлов А.И., Козлова М.А. Кортизол как маркер стресса : обзор // Физиология человека. – 2014. – Т. 40. №2. – С. 123-136.
5. Любошевский П.А., Овечкин А.М. Возможности оценки и коррекции хирургического стресс-ответа при операциях высокой травматичности // Регионарная анестезия и лечение острой боли. – 2014. – Т. 8. №4. – С. 5-21.
6. Day Y.J. Anesthesia, analgesia and surgical stress // Acta Anaesthesiol. Taiwan. – 2014. – Vol. 52. №2. – P. 47-48
7. Hubner M., Mantziari S., Demartines N., et al. Postoperative albumin drop is a marker for surgical stress and a predictor for clinical outcome: a pilot study // Gastroenterol. Res Pract. – 2016. – Vol. 6, № 4. – Р. 87-95.
8. Ilies C., Gruenewald M., Ludwigs J., et al. Evaluation of the surgical stress index during spinal and general anaesthesia // Br. J. Anaesth. – 2010. – Vol. 105, № 4. – Р. 533-537.
9. Ladron de Guevara H.D., Fumaro F.L., et al. Positron emission tomography/computed tomography for lung cancer staging // Rev. Med. Chil. – 2015. – Vol. 143. № 1. – Р. 22-29.
10. Schwartz R.M., Yip R., Olkin I., et al. Impact of surgery for stage IA non-small-cell lung cancer on patient quality of life // J. Communiti Support Oncol. – 2016. – Vol. 14. № 1. – Р. 37-44.
11. Stewart B.W., Wild C.P. Word Cancer Report. – Geneva, 2014. – 630 р.
12. Torre L.A., Siegel R.L., Jemal A. Lung Cancer Statistics // Adv. Exp. Med. Biol. – 2016. – Vol. 893. – Р. 1-19.
REFERENCES
1. Gorobets E.S, Karmanov I.E., Buydenok Yu.V. Epidural blockade as a component of anesthesia in oncologic surgeries of the lung. // Regionarnaya anesteziya i lechenie boli: Materialy Vserossiiskoi conferentsii. – Tver, 2004. – P. 134-140. (in Russian)
2. Gruzdev V.E., Gorobets E.S. Multimodal combined anesthesia as a method of anesthetic management of operations on the lungs in patients with low functional reserves of the respiratory // Regionarnaya anesteziya i lechenie boli. – 2013. – Vol. 7. № 3. – Р. 26-30. (in Russian)
3. Kachur S.V., Kachur A.K., Dolgikh V.T., Solovyev A.O. Assessment of hemodynamic profile in the intraoperative period in patients operated on for lung tumors in a multimodal anesthesia // Sibirskij Medicinskij Zurnal (Irkutsk). – 2015. - №3. – P. 67-69. (in Russian)
4. Kozlov A.I., Kozlova M.A. Cortizol as a marker of stress: overview // Physiologia cheloveka. – 2014. – Vol. 40. № 2. – Р. 123-136. (in Russian)
5. Lyuboshevsky P.A., Ovechkin A.M. Opportunities for evolution and correction of surgical stress response with operatic high trauma // Regionarnaya anesteziya i lechenie boli. – 2014. – Vol. 8. №4. – P. 5-21. (in Russian)
6. Day Y.J. Anesthesia, analgesia and surgical stress // Acta Anaesthesiol. Taiwan. – 2014. – Vol. 52, № 2. – P. 47-48.
7. Hubner M., Mantziari S., Demartines N., et al. Postoperative albumin drop is a marker for surgical stress and a predictor for clinical outcome: a pilot study // Gastroenterol. Res Pract. – 2016. – Vol. 4. № 6. – P. 87-95.
8. Ilies C., Gruenewald M., Ludwigs J., et al. Evaluation of the surgical stress index during spinal and general anaesthesia // Br. J. Anaesth. – 2010. – Vol. 105. №4. – P. 533-537.
9. Ladron de Guevara H.D., Fumaro F.L., Yevenes S.A., Miguel J. Positron emission tomography/computed tomography for lung cancer staging // Rev. Med. Chil. – 2015. – Vol. 143, № 1. – P. 22-29.
10. Schwartz R.M., Yip R., Olkin I., et al. Impact of surgery for stage IA non-small-cell lung cancer on patient quality of life // J. Communiti Support Oncol. – 2016. – Vol. 14, №1. – P. 37-44.
11. Stewart B.W., Wild C.P. Word Cancer Report. – Geneva, 2014. – 630 p.
12. Torre L.A., Siegel R.L., Jemal A. Lung Cancer Statistics // Adv. Exp. Med. Biol. – 2016. – Vol. 893. – P. 1-19.
Published
2018-04-10
How to Cite
КАЧУР, Светлана Владимировна; ДОЛГИХ, Владимир Терентьевич; ЛЕОНОВ, Олег Владимирович.
The effectiveness of the use of multimodal anesthesia in patientsoperated for neoplasms of lung.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 142, n. 3, p. 16-22, apr. 2018.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/146>. Date accessed: 18 feb. 2026.
Issue
Section
Original research
