Role of sensitization to Streptococcus pyogenes in children of early and preschool age with pharyngeal lymphoid ring hypertrophy in development of rheumatic reaction
Abstract
Streptococcus pyogenes is the reason of acute rheumatic fever and a post-streptococcal glomerulonephritis. Primary colonization of mucosal with this microorganism develops in the period of early ontogenesis. Clinic and immune features of the children with pharyngeal lymphoid ring hypertrophy of early and preschool age having the immune response to Streptococcus pyogenes were studied. Position of risk of formation of rheumatic diseases in these children was studied. 771 children, in an age interval of 2-6 years are examined. Immune and clinical indicators in two groups of the children having the immune response to Streptococcus pyogenes (basic, n=306) and not having it (n=465) were analyzed. The basic group of the children had a high level in a nasal secret of TNF-a, IL-4, INF-a, and in blood - ASL-O, ASG, RF, CRP and IgE. The atopic immune response to Streptococcus pyogenes, Streptococcus pneumoniae, S. aureus, Proteus vulgaris, Kl. pneumoniae,H. influenzae took place in the basic group. The conducted research showed that hyper productive immune reactions mainly on humoral type which can provide induction of rheumatic pathology are associated with the immune response to Streptococcus pyogenes; and detection of IgG antibodies to Streptococcus pyogenes can be screening for identification of group of risk on formation of rheumatic diseases among children with pharyngeal lymphoid ring hypertrophy.
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