The influence of metabolites of nitric oxide on mucociliary transport of nasal mucosa in patients with thyroid dysfunction
Abstract
The aim of the study was to investigate the content of NO metabolites in patients with changes in thyroid status and serum and nasal secretions and their effect on mucociliary activity. The study included 60 patients with thyroid pathology, the majority of which (91.6%) was identified as having high levels of NOХ metabolites in serum (51.95±2.55 μm) compared with the control group (p<0.001), which was associated with a confirmed slowing of mucociliary transport (17.0±0.9 min and 12.3±0.3 min, respectively; p<0.001). In patients with hormonal rhinitis on the background of dysfunction of the thyroid gland the metabolic disorders are the probable causes of chronic inflammation, in particular the imbalance in the synthesis of NO.
References
1. Агеева С.А. Состояние ЛОР органов при гипотиреозе: Автореф….дис. канд. мед. наук. – М., 1975. – 12 с.
2. Балаболкин М.И., Клебанова Е.М., Креминская В.М. Фундаментальная и клиническая тироидология. – М.: Медицина, 2007. – 816 с.
3. Захарова Г.П., Янов Ю.К., Шабалин В.В. Мукоцилиарная система верхних дыхательных путей. – СПб.: Диалог, 2010. – 360 с.
4. Ким И.А. Лечение полипозного риносинусита в послеоперационном периоде: автореф. дис. ... д-ра мед. наук. – СПб., 2009. – 43 с.
5. Пискунов Г.З., Пискунов С.З. Клиническая ринология. – М.: Литтерра, 2011. – 960 с.
6. Носуля Е.В., Черных Н.М. Мукоцилиарная активность у пациентов с патологией щитовидной железы // Российская ринология. – 2012. - №2. - С. 7.
7. Metel'skaia V.A., Gumanova N.G. Screening as a method for determining the serum level of nitric oxide metabolites // Klin. Lab. Diagn. – 2005. - №6. – P. 15-18.
8. Carrillo-Sepulveda M.A., Ceravolo G.S., Fortes Z.B., et al. Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes // Cardiovasc. Res. – 2010. – Vol. 85. – P. 560-570.
9. Maniscalco M., Sofia M., Pelaia G. Nitric oxide in upper airways inflammatory diseases // Inflamm. Res. – 2007. – Vol.56. №2. – Р. 8-69.
10. Miranda K.M., Espey M.G., Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite // Nitric Oxide. – 2001. – Vol. 5. №1. – Р. 62-71.
11. Lundberg J.O. Nitric oxide and the paranasal sinuses // Anat. Rec. (Hoboken). – 2008. – Vol. 291. №11. – Р. 1479-1484.
12. Napoli R., Biondi B., Guardasole V., et al. Impact of hyperthyroidism and its correction on vascular reactivity in humans // Circulation. – 2010. – Vol.104. – Р. 3076-3080.
13. Pravettoni V., Incorvaia C., Frati F. Role of measurement of nitric oxide in respiratory diseases // Recenti Prog Med. – 2008. – Vol. 99.№5. – Р.258-262.
14. Selimoglu E. Nitric oxide in health and disease from the point of view of the otorhinolaryngologist // Curr. Pharm. Des. – 2005. – Vol.11.№23. – Р. 3051-3060.
15. Wodehouse T., Kharitonov S.A., Mackay I.S., et al. Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia // Eur. Respir. J. – 2003. – Vol.21. №1. – Р. 43-47.
REFERENCES
1. Ageeva S.A. State ENT in hypothyroidism: Thesis PhD in Medicine. – Moscow, 1975. – 12 p. (in Russian)
2. Balabolkin M.I., Klebanova E.M., Kremensky V.M. Fundamental and clinical thyroidology. – Moscow: Meditsina, 2007. – 816 p. (in Russian)
3. Zakharova G.P., Janov Y.K., Shabalin V.V. Mucociliary system of the upper respiratory tract. – St. Petersburg: Dialog, 2010. – 360 p. (in Russian)
4. Kim I.A. Treatment of polypous rhinosinusitis in the postoperative period: Thesis DSc in Medicine. – St. Petersburg, 2009. – 43 p. (in Russian)
5. Piskunov G.Z., Piskunov S.Z. Clinical rhinology. – Moscow: Litterra, 2011. – 960 p. (in Russian)
6. Nosulya E.V., Chernykh N.M. Mucociliary activity in patients with pathology of thyroid gland // Russijskaya rinologya. – 2012. - №2. – P. 7. (in Russian)
7. Metel'skaia V.A., Gumanova N.G. Screening as a method for determining the serum level of nitric oxide metabolites // Klin. Lab. Diagn. – 2005. - №6. – P. 15-18.
8. Carrillo-Sepulveda M.A., Ceravolo G.S., Fortes Z.B., et al. Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes // Cardiovasc. Res. – 2010. – Vol. 85. – P. 560-570.
9. Maniscalco M., Sofia M., Pelaia G. Nitric oxide in upper airways inflammatory diseases // Inflamm. Res. – 2007. – Vol.56. №2. – Р. 8-69.
10. Miranda K.M., Espey M.G., Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite // Nitric Oxide. – 2001. – Vol. 5. №1. – Р. 62-71.
11. Lundberg J.O. Nitric oxide and the paranasal sinuses // Anat. Rec. (Hoboken). – 2008. – Vol. 291. №11. – Р. 1479-1484.
12. Napoli R., Biondi B., Guardasole V., et al. Impact of hyperthyroidism and its correction on vascular reactivity in humans // Circulation. – 2010. – Vol.104. – Р. 3076-3080.
13. Pravettoni V., Incorvaia C., Frati F. Role of measurement of nitric oxide in respiratory diseases // Recenti Prog Med. – 2008. – Vol. 99.№5. – Р.258-262.
14. Selimoglu E. Nitric oxide in health and disease from the point of view of the otorhinolaryngologist // Curr. Pharm. Des. – 2005. – Vol.11.№23. – Р. 3051-3060.
15. Wodehouse T., Kharitonov S.A., Mackay I.S., et al. Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia // Eur. Respir. J. – 2003. – Vol.21. №1. – Р. 43-47.
2. Балаболкин М.И., Клебанова Е.М., Креминская В.М. Фундаментальная и клиническая тироидология. – М.: Медицина, 2007. – 816 с.
3. Захарова Г.П., Янов Ю.К., Шабалин В.В. Мукоцилиарная система верхних дыхательных путей. – СПб.: Диалог, 2010. – 360 с.
4. Ким И.А. Лечение полипозного риносинусита в послеоперационном периоде: автореф. дис. ... д-ра мед. наук. – СПб., 2009. – 43 с.
5. Пискунов Г.З., Пискунов С.З. Клиническая ринология. – М.: Литтерра, 2011. – 960 с.
6. Носуля Е.В., Черных Н.М. Мукоцилиарная активность у пациентов с патологией щитовидной железы // Российская ринология. – 2012. - №2. - С. 7.
7. Metel'skaia V.A., Gumanova N.G. Screening as a method for determining the serum level of nitric oxide metabolites // Klin. Lab. Diagn. – 2005. - №6. – P. 15-18.
8. Carrillo-Sepulveda M.A., Ceravolo G.S., Fortes Z.B., et al. Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes // Cardiovasc. Res. – 2010. – Vol. 85. – P. 560-570.
9. Maniscalco M., Sofia M., Pelaia G. Nitric oxide in upper airways inflammatory diseases // Inflamm. Res. – 2007. – Vol.56. №2. – Р. 8-69.
10. Miranda K.M., Espey M.G., Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite // Nitric Oxide. – 2001. – Vol. 5. №1. – Р. 62-71.
11. Lundberg J.O. Nitric oxide and the paranasal sinuses // Anat. Rec. (Hoboken). – 2008. – Vol. 291. №11. – Р. 1479-1484.
12. Napoli R., Biondi B., Guardasole V., et al. Impact of hyperthyroidism and its correction on vascular reactivity in humans // Circulation. – 2010. – Vol.104. – Р. 3076-3080.
13. Pravettoni V., Incorvaia C., Frati F. Role of measurement of nitric oxide in respiratory diseases // Recenti Prog Med. – 2008. – Vol. 99.№5. – Р.258-262.
14. Selimoglu E. Nitric oxide in health and disease from the point of view of the otorhinolaryngologist // Curr. Pharm. Des. – 2005. – Vol.11.№23. – Р. 3051-3060.
15. Wodehouse T., Kharitonov S.A., Mackay I.S., et al. Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia // Eur. Respir. J. – 2003. – Vol.21. №1. – Р. 43-47.
REFERENCES
1. Ageeva S.A. State ENT in hypothyroidism: Thesis PhD in Medicine. – Moscow, 1975. – 12 p. (in Russian)
2. Balabolkin M.I., Klebanova E.M., Kremensky V.M. Fundamental and clinical thyroidology. – Moscow: Meditsina, 2007. – 816 p. (in Russian)
3. Zakharova G.P., Janov Y.K., Shabalin V.V. Mucociliary system of the upper respiratory tract. – St. Petersburg: Dialog, 2010. – 360 p. (in Russian)
4. Kim I.A. Treatment of polypous rhinosinusitis in the postoperative period: Thesis DSc in Medicine. – St. Petersburg, 2009. – 43 p. (in Russian)
5. Piskunov G.Z., Piskunov S.Z. Clinical rhinology. – Moscow: Litterra, 2011. – 960 p. (in Russian)
6. Nosulya E.V., Chernykh N.M. Mucociliary activity in patients with pathology of thyroid gland // Russijskaya rinologya. – 2012. - №2. – P. 7. (in Russian)
7. Metel'skaia V.A., Gumanova N.G. Screening as a method for determining the serum level of nitric oxide metabolites // Klin. Lab. Diagn. – 2005. - №6. – P. 15-18.
8. Carrillo-Sepulveda M.A., Ceravolo G.S., Fortes Z.B., et al. Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes // Cardiovasc. Res. – 2010. – Vol. 85. – P. 560-570.
9. Maniscalco M., Sofia M., Pelaia G. Nitric oxide in upper airways inflammatory diseases // Inflamm. Res. – 2007. – Vol.56. №2. – Р. 8-69.
10. Miranda K.M., Espey M.G., Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite // Nitric Oxide. – 2001. – Vol. 5. №1. – Р. 62-71.
11. Lundberg J.O. Nitric oxide and the paranasal sinuses // Anat. Rec. (Hoboken). – 2008. – Vol. 291. №11. – Р. 1479-1484.
12. Napoli R., Biondi B., Guardasole V., et al. Impact of hyperthyroidism and its correction on vascular reactivity in humans // Circulation. – 2010. – Vol.104. – Р. 3076-3080.
13. Pravettoni V., Incorvaia C., Frati F. Role of measurement of nitric oxide in respiratory diseases // Recenti Prog Med. – 2008. – Vol. 99.№5. – Р.258-262.
14. Selimoglu E. Nitric oxide in health and disease from the point of view of the otorhinolaryngologist // Curr. Pharm. Des. – 2005. – Vol.11.№23. – Р. 3051-3060.
15. Wodehouse T., Kharitonov S.A., Mackay I.S., et al. Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia // Eur. Respir. J. – 2003. – Vol.21. №1. – Р. 43-47.
Published
2018-04-16
How to Cite
ЧЕРНЫХ, Наталья Михайловна et al.
The influence of metabolites of nitric oxide on mucociliary transport of nasal mucosa in patients with thyroid dysfunction.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 139, n. 8, p. 18-21, apr. 2018.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/215>. Date accessed: 28 jan. 2026.
Issue
Section
Original research
