Cryoregenerative applicaion in an idiopathic necrosis of the femoral head in an experiment
Abstract
The study included 24 rabbits of both sexes. After experimental detection of the optimal cryoregenerative refrigerant exposure, animals underwent a number of surgical interventions against asynthetic necrosis of the femoral head due to tunneling and cryoexposure to the focus of osteonecrosis for optimizing osteoreparative processes of bone tissue in the animals of the group, the group basis and tunneling without cryoexposure in animals of the comparison group. The control group consisted of 8 animals, which did not undergo surgical interventions. According to the data of histomorphological studies, we detected an actively developing neo-osteogenesis, which indicates the effectiveness of the 3-second exposure procedure for optimizing osteohystogenesis under the experimental model of aseptic necrosis of the femoral head. The obtained results of experimental studies make it possible to apply the proposed developed method of cryoapplication to pathologically altered bone tissue in the treatment of Legg-Calve-Perthes disease in a necrotically altered head.
References
2. Синюк И.В., Дударев В.А. Лечение болезни Пертеса методом регенерации костной ткани // Международный журнал экспериментального образования. – 2015. – Т. 5. № 5. – C. 404-406.
3. Слизовский Г.В., Кужеливский И.И. Современное состояние проблемы лечения костной патологии у детей // Бюллетень сибирской медицины. –2012. – № 2. – С. 64-77.
4. Слизовский Г.В., Кужеливский И.И., Ситко Л.А. Современное состояние проблемы лечения заболеваний костно-суставной системы у детей // Мать и дитя в Кузбассе. – 2015. – Т. 63. № 4. – С. 4-12.
5. Слизовский Г.В., Кужеливский И.И., Ситко Л.А. Субдеструктивное криовоздействие на костную ткань в эксперименте // Вестник экспериментальной и клинической хирургии. – 2017. – Т. 10. № 1. – С. 44-48. – DOI: 10.18499/2070-478X-2017-10-1-44-48.
6. Слизовский Г.В., Масликов В.М., Гюнтер В.Э., Титов М.В., Кузнецов Е.В., Кужеливский И.И. Хирургическое лечение килевидной деформации грудной клетки у детей с применением материалов из никелида титана // Бюллетень сибирской медицины. – 2011. – Т. 10. № 4. – С. 161-165.
7. Слизовский Г.В., Кужеливский И.И., Уразова О.И. Устройство для хирургического лечения болезни Пертеса. Патент РФ на полезную модель № 153023 от 27.06.2015 г.
References
1. Krest'yashin I.V., Razumovskiy A.Yu., Krest'yashin V.M., Domarev A.O., Slizovskiy G.V., Kuzhelivskiy I.I. Modern technologies substituting outpatient for inpatient care in the work of the childrens centre of outpatient surgery, traumatology and orthopedics // Sibirskiy meditsinskiy zhurnal (Irkutsk) - Siberian Medical Journal (Irkutsk). – 2016. – Vol. 146. № 7. – P. 25-28. (in Russsian)
2. Sinyuk I.V., Dudarev V.A. Treatment of Perthes’ disease by bone regeneration // Mezhdunarodnyy zhurnal eksperimental'nogo obrazovaniya. – 2015. – Vol. 5. № 5. – P. 404-406. (in Russian)
3. Slizovskiy G.V., Kuzhelivskiy I.I. State of the art of the treatment of bone pathology in children // Byulleten' sibirskoy meditsiny - Bulletin of Siberian Medicine. – 2012. – Vol. 11. № 2. – P. 64-77. (in Russian)
4. Slizovskiy G.V., Kuzhelivskiy I.I., Sitko L.A. Current status of treatment for diseases of the osteoarticular system in children // Mat' i ditya v Kuzbasse - Mother and Baby in Kuzbass. – 2015. – Vol. 63. № 4. – P. 4-12. (in Russsian)
5. Slizovskiy G.V., Kuzhelivskiy I.I., Sitko L.A. Bone subdestructive kryoapplicaton in the experiment // Vestnik eksperimental'noy i klinicheskoy khirurgii. – 2017. – Vol. 10. № 1. – P. 44–48. (in Russian). – DOI: 10.18499/2070-478X-2017-10-1-44-48
6. Slizovskiy G.V., Maslikov V.M., Gyunter V.E., Titov M.V., Kuznetsov E.V., Kuzhelivskiy I.I. Surgical treatment of keeled chest in children using titanium nickelide materials // Byulleten' sibirskoy meditsiny - Bulletin of Siberian Medicine. – 2011. – Vol. 10. № 4. – P. 161-165. (in Russian)
7. Slizovskiy G.V., Kuzhelivskiy I.I., Urazova O.I. Device for surgical treatment of Perthes disease. Russian Federation patent RU 153023. 2015 Jun 27 (in Russian)
