The influence of coronary artery bypass graft on inflammation and miocardial injury in patients with coronary heart disease
Abstract
Purpose. To estimate the influence of coronary artery bypass graft on imflammation and miocardial injury markers in patients with coronary heart disease. Methods. We enrolled 96 patients in whom interleukin - 6 (IL-6), interleukin - 8 (IL-8), interleukin - 10 (IL-10), C-reactive protein (CRP), fibrinogen and troponin levels were studied. Results. Determination of white blood cells and leukocyte counts showed a significant increase of these indicators after reconstructive surgery. We found significantly higher mean concentration of IL-6 and fibrinogen in postoperative period (21,4±30,7 pg/ml versus 47,2±57,1 pg/ml, р<0,0001 and 3,3±0,9 g/l versus 4,3±1,1 g/l, р<0,0001 respectively). IL-8, IL-10 and CRP also raised in postoperative period, but remained within normal range. Mean troponin level was significantly higher in postoperative period (0 versus 2,8±2,2 mcg/l, р<0,0001).Conclusion. An increasing of white blood cells, fibrinogen and interleukin-6 in postoperative period is accompanied with an increasing of systemic inflammation. Coronary artery bypass graft leads to miocardial ischemia, which is accompanied with an increasing of troponin levels.
References
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9. Jackevicius C.A., Alter D., Cox J., et al. Acute treatment of myocardial infarction in Canada 1999-2002 // Can J Cardiol. – 2005. – Vol. 21(2). – Р. 145-52.
10. Jongman R.M., Zijlstra J.G., Kok W.F., et al. Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study // Shock. – 2014. – Vol. 42(2). – Р. 121-128.
11. Karu I., Starkopf J., Zilmer K., Zilmer M. Growth factors serum levels in coronary artery disease patients scheduled for bypass surgery: perioperative dynamics and comparisons with healthy volunteers // Biomed Res Int. – 2013. – Vol. 2013. – Р. 985404.
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13. Li P.J., Wei M.X., Liu J.S., et al. Effect of pericardial suction blood re-transfusion in off-pump coronary artery bypass grafting on inflammatory cytokines, myocardial injury and pulmonary function // Zhonghua. Wai. Ke. Za. Zhi. – 2008. – Vol. 46(9). – Р. 677-680.
14. Mirhafez S.R., Zarifian A., Ebrahimi M., et al. Relationship between serum cytokine and growth factor concentrations and coronary artery disease // Clin Biochem. – 2015. – Vol. 48(9). – Р. 575-580.
15. Miwa K., Tanaka M., Okazaki S., et al. Association between interleukin-6 levels and first-ever cerebrovascular events in patients with vascular risk factors // Arterioscler Thromb Vasc Biol. – 2013. – Vol. 33. – Р. 400-405.
16. Packard R.S., Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction // Clin. Chem. – 2008. – Vol. 54 – Р. 24-38.
17. Palmerini T., Marzocchi A., Marrozzini C., et al. Preprocedural levels of C-reactive protein and leukocyte counts predict 9 month mortality after coronary artery stenosis // Circulation. – 2005. – Vol. 112. – P. 2332-2338.
18. Roy S., Saha K., Mukherjee K., et al. Activation of coagulation and fibrinolysis during coronary artery bypass grafting: a comparison between on-pump and off-pump techniques // Indian J Hematol Blood Transfus. – 2014. – Vol. 30(4). – Р. 333-41.
19. Uyar I.S., Onal S., Uysal A., et al. Evaluation of systemic inflammatory response in cardiovascular surgery via interleukin-6, interleukin-8, and neopterin // Heart Surg Forum. – 2014. - №17(1). – Р. E13-7.
REFERENCES
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2. Panchenko E.P., Belenkov Y.N. Characteristics and outcomes of atherotrombosis in outpatients in Russian Federation (REACH registry) // Kardiologiya. – 2008. - №2. – P. 17-24. (in Russian)
3. Rubanenko О.А. Correction of dyslipidemia in patients with coronary artery disease categories of high and very high risk of heart // Aspirantskiy vestnik Povolzhya. Meditsina. Nauchnyie stati molodyih uchenyih. - 2009. – № 3-4. – P. 65-68. (in Russian)
4. Chasova I.E., Chuchalin A.G., Zyikov K.A. Diagnostics and treatment of patients with hypertension and obstructive lung disease (Guidelines of Russian medical society of hypertension and Russian respiratory society) // Sistemnyie Gipertenzii. – 2013. – №10. – P. 5-34. (in Russian)
5. Shalnova S.A., Konradi A.O., Karpov Yu.A., et al. The analisys of cardiovascular death in 12 regions of Russian Federation, enrolled in the study "Epidemiology of cardiovascular disease in different regions of Russian Federation" // Rossiyskiy kardiologicheskiy zhurnal. – 2012. - №5. – Р. 6-11. (in Russian)
6. Efros L.A., Kaleev O.F. Comorbidities in patients with coronary heart disease after coronary artery bypass graft // Polipatii v semeynoy i klinicheskoy meditsine: materialyi vseros. nauch.-praktich. konf., posvyasch. 75-letiyu zasluzhennogo deyatelya nauki RF, professora O.F. Kaleva – Chelyabinsk: Izd-vo GOU VPO ChelGMA Roszdrava, 2013. – Р. 228-234. (in Russian)
7. Bhatt D.L., Steg P.G., Ohman E.M., et al. International prevalence, recognition, and treatment of cardiovascular risk factor in outpatient with atherothrombosis // JAMA. – 2006. – Vol. 295(2). – Р. 180-189.
8. Buckberg G.D. Myocardial protection: entering the new millennium // J Card Surg. – 2002. - №17. – Р. 447–450.
9. Jackevicius C.A., Alter D., Cox J., et al. Acute treatment of myocardial infarction in Canada 1999-2002 // Can J Cardiol. – 2005. – Vol. 21(2). – Р. 145-52.
10. Jongman R.M., Zijlstra J.G., Kok W.F., et al. Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study // Shock. – 2014. – Vol. 42(2). – Р. 121-128.
11. Karu I., Starkopf J., Zilmer K., Zilmer M. Growth factors serum levels in coronary artery disease patients scheduled for bypass surgery: perioperative dynamics and comparisons with healthy volunteers // Biomed Res Int. – 2013. – Vol. 2013. – Р. 985404.
12. Kovacević R., Majkić-Singh N., Ignjatović S., et al. Troponin T levels in detection of perioperative myocardial infarction after coronary artery bypass surgery // Clin Lab. – 2004. – Vol. 50. – Р. 437–445.
13. Li P.J., Wei M.X., Liu J.S., et al. Effect of pericardial suction blood re-transfusion in off-pump coronary artery bypass grafting on inflammatory cytokines, myocardial injury and pulmonary function // Zhonghua. Wai. Ke. Za. Zhi. – 2008. – Vol. 46(9). – Р. 677-680.
14. Mirhafez S.R., Zarifian A., Ebrahimi M., et al. Relationship between serum cytokine and growth factor concentrations and coronary artery disease // Clin Biochem. – 2015. – Vol. 48(9). – Р. 575-580.
15. Miwa K., Tanaka M., Okazaki S., et al. Association between interleukin-6 levels and first-ever cerebrovascular events in patients with vascular risk factors // Arterioscler Thromb Vasc Biol. – 2013. – Vol. 33. – Р. 400-405.
16. Packard R.S., Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction // Clin. Chem. – 2008. – Vol. 54 – Р. 24-38.
17. Palmerini T., Marzocchi A., Marrozzini C., et al. Preprocedural levels of C-reactive protein and leukocyte counts predict 9 month mortality after coronary artery stenosis // Circulation. – 2005. – Vol. 112. – P. 2332-2338.
18. Roy S., Saha K., Mukherjee K., et al. Activation of coagulation and fibrinolysis during coronary artery bypass grafting: a comparison between on-pump and off-pump techniques // Indian J Hematol Blood Transfus. – 2014. – Vol. 30(4). – Р. 333-41.
19. Uyar I.S., Onal S., Uysal A., et al. Evaluation of systemic inflammatory response in cardiovascular surgery via interleukin-6, interleukin-8, and neopterin // Heart Surg Forum. – 2014. - №17(1). – Р. E13-7.
2. Панченко Е.П. Беленков Ю.Н. Характеристика и исходы атеротромбоза у амбулаторных больных в Российской Федерации (по материалам международного регистра REACH) // Кардиология. – 2008. - №2. – С. 17-24.
3. Рубаненко О.А. Коррекция дислипидемий у больных ишемической болезнью сердца категорий высокого и очень высокого риска // Аспирантский вестник Поволжья. Медицина. Научные статьи молодых ученых. – 2009. – №3-4. – С. 65-68.
4. Чазова И.Е., Чучалин А.Г., Зыков К.А. и др. Диагностика и лечение пациентов с артериальной гипертонией и хронической обструктивной болезнью легких (Рекомендации Российского медицинского общества по артериальной гипертонии и Российского респираторного общества) // Системные гипертензии. – 2013. - №10. – С. 5-34.
5. Шальнова С.А., Конради А.О., Карпов Ю.А. с соавт. Анализ смертности от сердечно-сосудистых заболеваний в 12 регионах Российской Федерации, участвующих в исследовании «Эпидемиология сердечно-сосудистых заболеваний в различных регионах России» // Российский кардиологический журнал. – 2012. - №5. – С. 6-11.
6. Эфрос Л.А., Калев О.Ф. Сопутствующая патология у больных ишемической болезнью сердца после коронарного шунтирования // Полипатии в семейной и клинической медицине: материалы всероссийской научно-практической конференции, посвящённой 75-летию заслуженного деятеля науки РФ, профессора О.Ф. Калева. – Челябинск: Изд-во ГОУ ВПО ЧелГМА Росздрава, 2013 – С. 228–234.
7. Bhatt D.L., Steg P.G., Ohman E.M., et al. International prevalence, recognition, and treatment of cardiovascular risk factor in outpatient with atherothrombosis // JAMA. – 2006. – Vol. 295(2). – Р. 180-189.
8. Buckberg G.D. Myocardial protection: entering the new millennium // J Card Surg. – 2002. - №17. – Р. 447–450.
9. Jackevicius C.A., Alter D., Cox J., et al. Acute treatment of myocardial infarction in Canada 1999-2002 // Can J Cardiol. – 2005. – Vol. 21(2). – Р. 145-52.
10. Jongman R.M., Zijlstra J.G., Kok W.F., et al. Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study // Shock. – 2014. – Vol. 42(2). – Р. 121-128.
11. Karu I., Starkopf J., Zilmer K., Zilmer M. Growth factors serum levels in coronary artery disease patients scheduled for bypass surgery: perioperative dynamics and comparisons with healthy volunteers // Biomed Res Int. – 2013. – Vol. 2013. – Р. 985404.
12. Kovacević R., Majkić-Singh N., Ignjatović S., et al. Troponin T levels in detection of perioperative myocardial infarction after coronary artery bypass surgery // Clin Lab. – 2004. – Vol. 50. – Р. 437–445.
13. Li P.J., Wei M.X., Liu J.S., et al. Effect of pericardial suction blood re-transfusion in off-pump coronary artery bypass grafting on inflammatory cytokines, myocardial injury and pulmonary function // Zhonghua. Wai. Ke. Za. Zhi. – 2008. – Vol. 46(9). – Р. 677-680.
14. Mirhafez S.R., Zarifian A., Ebrahimi M., et al. Relationship between serum cytokine and growth factor concentrations and coronary artery disease // Clin Biochem. – 2015. – Vol. 48(9). – Р. 575-580.
15. Miwa K., Tanaka M., Okazaki S., et al. Association between interleukin-6 levels and first-ever cerebrovascular events in patients with vascular risk factors // Arterioscler Thromb Vasc Biol. – 2013. – Vol. 33. – Р. 400-405.
16. Packard R.S., Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction // Clin. Chem. – 2008. – Vol. 54 – Р. 24-38.
17. Palmerini T., Marzocchi A., Marrozzini C., et al. Preprocedural levels of C-reactive protein and leukocyte counts predict 9 month mortality after coronary artery stenosis // Circulation. – 2005. – Vol. 112. – P. 2332-2338.
18. Roy S., Saha K., Mukherjee K., et al. Activation of coagulation and fibrinolysis during coronary artery bypass grafting: a comparison between on-pump and off-pump techniques // Indian J Hematol Blood Transfus. – 2014. – Vol. 30(4). – Р. 333-41.
19. Uyar I.S., Onal S., Uysal A., et al. Evaluation of systemic inflammatory response in cardiovascular surgery via interleukin-6, interleukin-8, and neopterin // Heart Surg Forum. – 2014. - №17(1). – Р. E13-7.
REFERENCES
1. Oganov R.G., Kontsevaya A.V., Kalinina A.M. Economic burden of cardiovascular disease in the Russian Federation // Kardiovaskulyarnaya terapiya i profilaktika. – 2011. - №10(4). – Р. 4–9. (in Russian)
2. Panchenko E.P., Belenkov Y.N. Characteristics and outcomes of atherotrombosis in outpatients in Russian Federation (REACH registry) // Kardiologiya. – 2008. - №2. – P. 17-24. (in Russian)
3. Rubanenko О.А. Correction of dyslipidemia in patients with coronary artery disease categories of high and very high risk of heart // Aspirantskiy vestnik Povolzhya. Meditsina. Nauchnyie stati molodyih uchenyih. - 2009. – № 3-4. – P. 65-68. (in Russian)
4. Chasova I.E., Chuchalin A.G., Zyikov K.A. Diagnostics and treatment of patients with hypertension and obstructive lung disease (Guidelines of Russian medical society of hypertension and Russian respiratory society) // Sistemnyie Gipertenzii. – 2013. – №10. – P. 5-34. (in Russian)
5. Shalnova S.A., Konradi A.O., Karpov Yu.A., et al. The analisys of cardiovascular death in 12 regions of Russian Federation, enrolled in the study "Epidemiology of cardiovascular disease in different regions of Russian Federation" // Rossiyskiy kardiologicheskiy zhurnal. – 2012. - №5. – Р. 6-11. (in Russian)
6. Efros L.A., Kaleev O.F. Comorbidities in patients with coronary heart disease after coronary artery bypass graft // Polipatii v semeynoy i klinicheskoy meditsine: materialyi vseros. nauch.-praktich. konf., posvyasch. 75-letiyu zasluzhennogo deyatelya nauki RF, professora O.F. Kaleva – Chelyabinsk: Izd-vo GOU VPO ChelGMA Roszdrava, 2013. – Р. 228-234. (in Russian)
7. Bhatt D.L., Steg P.G., Ohman E.M., et al. International prevalence, recognition, and treatment of cardiovascular risk factor in outpatient with atherothrombosis // JAMA. – 2006. – Vol. 295(2). – Р. 180-189.
8. Buckberg G.D. Myocardial protection: entering the new millennium // J Card Surg. – 2002. - №17. – Р. 447–450.
9. Jackevicius C.A., Alter D., Cox J., et al. Acute treatment of myocardial infarction in Canada 1999-2002 // Can J Cardiol. – 2005. – Vol. 21(2). – Р. 145-52.
10. Jongman R.M., Zijlstra J.G., Kok W.F., et al. Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study // Shock. – 2014. – Vol. 42(2). – Р. 121-128.
11. Karu I., Starkopf J., Zilmer K., Zilmer M. Growth factors serum levels in coronary artery disease patients scheduled for bypass surgery: perioperative dynamics and comparisons with healthy volunteers // Biomed Res Int. – 2013. – Vol. 2013. – Р. 985404.
12. Kovacević R., Majkić-Singh N., Ignjatović S., et al. Troponin T levels in detection of perioperative myocardial infarction after coronary artery bypass surgery // Clin Lab. – 2004. – Vol. 50. – Р. 437–445.
13. Li P.J., Wei M.X., Liu J.S., et al. Effect of pericardial suction blood re-transfusion in off-pump coronary artery bypass grafting on inflammatory cytokines, myocardial injury and pulmonary function // Zhonghua. Wai. Ke. Za. Zhi. – 2008. – Vol. 46(9). – Р. 677-680.
14. Mirhafez S.R., Zarifian A., Ebrahimi M., et al. Relationship between serum cytokine and growth factor concentrations and coronary artery disease // Clin Biochem. – 2015. – Vol. 48(9). – Р. 575-580.
15. Miwa K., Tanaka M., Okazaki S., et al. Association between interleukin-6 levels and first-ever cerebrovascular events in patients with vascular risk factors // Arterioscler Thromb Vasc Biol. – 2013. – Vol. 33. – Р. 400-405.
16. Packard R.S., Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction // Clin. Chem. – 2008. – Vol. 54 – Р. 24-38.
17. Palmerini T., Marzocchi A., Marrozzini C., et al. Preprocedural levels of C-reactive protein and leukocyte counts predict 9 month mortality after coronary artery stenosis // Circulation. – 2005. – Vol. 112. – P. 2332-2338.
18. Roy S., Saha K., Mukherjee K., et al. Activation of coagulation and fibrinolysis during coronary artery bypass grafting: a comparison between on-pump and off-pump techniques // Indian J Hematol Blood Transfus. – 2014. – Vol. 30(4). – Р. 333-41.
19. Uyar I.S., Onal S., Uysal A., et al. Evaluation of systemic inflammatory response in cardiovascular surgery via interleukin-6, interleukin-8, and neopterin // Heart Surg Forum. – 2014. - №17(1). – Р. E13-7.
Published
2018-04-16
How to Cite
РУБАНЕНКО, Олеся Анатольевна.
The influence of coronary artery bypass graft on inflammation and miocardial injury in patients with coronary heart disease.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 140, n. 1, p. 18-22, apr. 2018.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/190>. Date accessed: 28 jan. 2026.
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Section
Original research
