Morphology of neuroendocrine tumors of the digestive system
Abstract
In recent years, special attention is paid to neuroendocrine tumors of the digestive system, formerly known as carcinoids. Not-quite the same kind of looking at the morphology of these tumor localization in different parts of the gastrointestinal tract have different biological behavior, potential malignancy. Morphological sub-study course to defined criteria is of particular relevance for their classification, rubrification and especially to predict the subsequent course of the disease
References
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11. Jamali M., Chetty R. Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining. – Endocr Pathol. – 2008. – Vol. 19 (4). – P. 282-8.
12. Klimstra D., Modlin I., Adsay N., et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set // Am. J. Surg. Pathol. – 2010. – Vol. 34 (3). – P. 300-313.
13. Klimstra D.S. Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging // Semin Oncol. – 2013. – Vol. 40(1). – P. 23-36.
14. Klöppel G. Tumour biology and histopathology of neuroendocrine tumours // Best Pract Res Clin Endocrinol Metab. – 2007. – Vol. 21(1). – P. 15-31.
15. Klöppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms // Endocr Relat Cancer. – 2011. – Vol.18 (Suppl 1). – P. S1-16.
16. Klöppel G., Rindi G., Perren A., et al. The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement // Virchows Arch. – 2010. – Vol. 456(6). – P. 595-597.
17. Modlin I.M., Pavel M., Kidd M., Gustafsson B.I. Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours //Aliment Pharmacol Ther. – 2010. – Vol. 31(2). – P. 169-188.
18. Remes S.M., Tuominen V.J., Helin H., et al. Grading of neuroendocrine tumors with Ki-67 requires high-quality assessment practices // Am J Surg Pathol. – 2012. – Vol. 36(9). – P.1359-1363.
19. Rindi G., Klöppel G., Alhman H., et al. TNM staging of foregut (neuro) endocrine tumors: a consensus proposal including a grading system // Virchows Arch. – 2006. – Vol. 449(4). – P. 395-401.
20. Scoazec J.Y., Couvelard A. Gastroenteropancreatic neuroendocrine tumors: what must the pathologist know and do in 2014? // Ann Pathol. – 2014. – Vol. 34 (1). – P. 40-50.
21. Sidéris L., Dubé P., Rinke A. Antitumor effects of somatostatin analogs in neuroendocrine tumors // Oncologist. – 2012. – Vol. 17(6). – P. 747-755.
22. Solcia E., Kloppel G., Sobin L., et al. Histological typing of endocrine tumours: WHO international histological classifi cationof tumors. – Berlin: Springer, 2000. – S. 223-245.
REFERENCES
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2. Gurevich L.E., Delektorskaya V.V. Prospects for revision of the histological classification of neuroendocrine tumors // Sovremennaya onkologiya. – 2014. – No3. – P. 86-90. (in Russian)
3. Delektorskaya V.V., Kushlinskiy N.E. Neuroendocrine Tumors of Digestive System: Morphologic Spectrum and Cell Proliferation (КІ67 index) // Vestnik Rossiyskoy akademii meditsinskih nauk. – 2013. – №5. – P. 28-37. (in Russian)
4. Keplin M., Kvols L. Neuroendocrine tumors: Guidelines for doctors. – Moscow: Prakticheskaya meditsina, 2011. – 224 p. (in Russian)
5. Markovich A.A., Orel N.F., Lyubimova N.V. Biochemical Markers in Diagnostics and Treatment of Neuroendocrine Tumors // Voprosyi biologicheskoy, meditsinskoy i farmatsevticheskoy himii. – 2011. – №12. – P. 28-36. (in Russian)
6. Pinskiy S.B., Beloborodov V.A., Batoroev Yu.K., Dvornichenko V.V. Gastrointestinal neuroendocrine tumors (report 3). Neuroendocrine tumors of the stomach // Sibirskij Medicinskij Zurnal (Irkutsk). – 2015. – №1. – P. 17-24. (in Russian)
7. Pinskiy S.B., Beloborodov V.A., Batoroev Yu.K., Dvornichenko V.V. Gastrointestinal neuroendocrine tumors (report 4). Neuroendocrine tumors of the small intectine // Sibirskij Medicinskij Zurnal (Irkutsk). – 2015. – №2. – P. 10-16. (in Russian)
8. Bosman F., Carniero F., Hruban R., Tneise N. WHO Classification of Tumors of Digestive System – Lyon, IARC, Press. – 2010.
9. Boussaha T., Rougier P., Taieb J., Lepere C. Digestive neuroendocrine tumors (DNET): the era of targeted therapies // Clin Res Hepatol Gastroenterol. – 2013. – Vol.37. – P. 134-141.
10. Couvelard A. Ki67 and neuroendocrine tumors // Ann Pathol. – 2011. – Vol. 31 (5) Suppl. – P. S55-S56.
11. Jamali M., Chetty R. Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining. – Endocr Pathol. – 2008. – Vol. 19 (4). – P. 282-8.
12. Klimstra D., Modlin I., Adsay N., et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set // Am. J. Surg. Pathol. – 2010. – Vol. 34 (3). – P. 300-313.
13. Klimstra D.S. Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging // Semin Oncol. – 2013. – Vol. 40(1). – P. 23-36.
14. Klöppel G. Tumour biology and histopathology of neuroendocrine tumours // Best Pract Res Clin Endocrinol Metab. – 2007. – Vol. 21(1). – P. 15-31.
15. Klöppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms // Endocr Relat Cancer. – 2011. – Vol.18 (Suppl 1). – P. S1-16.
16. Klöppel G., Rindi G., Perren A., et al. The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement // Virchows Arch. – 2010. – Vol. 456(6). – P. 595-597.
17. Modlin I.M., Pavel M., Kidd M., Gustafsson B.I. Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours //Aliment Pharmacol Ther. – 2010. – Vol. 31(2). – P. 169-188.
18. Remes S.M., Tuominen V.J., Helin H., et al. Grading of neuroendocrine tumors with Ki-67 requires high-quality assessment practices // Am J Surg Pathol. – 2012. – Vol. 36(9). – P.1359-1363.
19. Rindi G., Klöppel G., Alhman H., et al. TNM staging of foregut (neuro) endocrine tumors: a consensus proposal including a grading system // Virchows Arch. – 2006. – Vol. 449(4). – P. 395-401.
20. Scoazec J.Y., Couvelard A. Gastroenteropancreatic neuroendocrine tumors: what must the pathologist know and do in 2014? // Ann Pathol. – 2014. – Vol. 34 (1). – P. 40-50.
21. Sidéris L., Dubé P., Rinke A. Antitumor effects of somatostatin analogs in neuroendocrine tumors // Oncologist. – 2012. – Vol. 17(6). – P. 747-755.
22. Solcia E., Kloppel G., Sobin L., et al. Histological typing of endocrine tumours: WHO international histological classifi cationof tumors. – Berlin: Springer, 2000. – S. 223-245.
2. Гуревич Л.Е., Делекторская В.В. Перспективы пересмотра гистологических классификаций нейроэндокринных опухолей // Современная онкология. – 2014. – №3. – С. 86-90.
3. Делекторская В.В., Кушлинский Н.Е. Нейроэндокринные опухоли пищеварительной системы: морфологический спектр и клеточная пролиферация (индекс Ki67) // Вестник Российской академии медицинских наук. – 2013. – № 5. – С. 28-37.
4. Кэплин М., Кволс Л. Нейроэндокринные опухоли: Руководство для врачей. – М.: Практическая медицина, 2011. – 224 с.
5. Маркович А.А., Орел Н.Ф., Любимова Н.В. Биохимические маркеры в диагностике и лечении нейроэндокринных опухолей // Вопросы биологической, медицинской и фармацевтической химии. – 2011. – №12. – С. 28-36.
6. Пинский С.Б., Белобородов В.А., Батороев Ю.К., Дворниченко В.В. Нейроэндокринные опухоли желудочно-кишечного тракта (сообщение 3) нейроэндокринные опухоли желудка // Сибирский медицинский журнал (Иркутск). – 2015. – №1. – С. 17-24.
7. Пинский С.Б., Белобородов В.А., Батороев Ю.К., Дворниченко В.В. Нейроэндокринные опухоли желудочно-кишечного тракта (сообщение 4) нейроэндокринные опухоли тонкой кишки // Сибирский медицинский журнал (Иркутск). – 2015. – №2. – С. 10-16.
8. Bosman F., Carniero F., Hruban R., Tneise N. WHO Classification of Tumors of Digestive System – Lyon, IARC, Press. – 2010.
9. Boussaha T., Rougier P., Taieb J., Lepere C. Digestive neuroendocrine tumors (DNET): the era of targeted therapies // Clin Res Hepatol Gastroenterol. – 2013. – Vol.37. – P. 134-141.
10. Couvelard A. Ki67 and neuroendocrine tumors // Ann Pathol. – 2011. – Vol. 31 (5) Suppl. – P. S55-S56.
11. Jamali M., Chetty R. Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining. – Endocr Pathol. – 2008. – Vol. 19 (4). – P. 282-8.
12. Klimstra D., Modlin I., Adsay N., et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set // Am. J. Surg. Pathol. – 2010. – Vol. 34 (3). – P. 300-313.
13. Klimstra D.S. Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging // Semin Oncol. – 2013. – Vol. 40(1). – P. 23-36.
14. Klöppel G. Tumour biology and histopathology of neuroendocrine tumours // Best Pract Res Clin Endocrinol Metab. – 2007. – Vol. 21(1). – P. 15-31.
15. Klöppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms // Endocr Relat Cancer. – 2011. – Vol.18 (Suppl 1). – P. S1-16.
16. Klöppel G., Rindi G., Perren A., et al. The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement // Virchows Arch. – 2010. – Vol. 456(6). – P. 595-597.
17. Modlin I.M., Pavel M., Kidd M., Gustafsson B.I. Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours //Aliment Pharmacol Ther. – 2010. – Vol. 31(2). – P. 169-188.
18. Remes S.M., Tuominen V.J., Helin H., et al. Grading of neuroendocrine tumors with Ki-67 requires high-quality assessment practices // Am J Surg Pathol. – 2012. – Vol. 36(9). – P.1359-1363.
19. Rindi G., Klöppel G., Alhman H., et al. TNM staging of foregut (neuro) endocrine tumors: a consensus proposal including a grading system // Virchows Arch. – 2006. – Vol. 449(4). – P. 395-401.
20. Scoazec J.Y., Couvelard A. Gastroenteropancreatic neuroendocrine tumors: what must the pathologist know and do in 2014? // Ann Pathol. – 2014. – Vol. 34 (1). – P. 40-50.
21. Sidéris L., Dubé P., Rinke A. Antitumor effects of somatostatin analogs in neuroendocrine tumors // Oncologist. – 2012. – Vol. 17(6). – P. 747-755.
22. Solcia E., Kloppel G., Sobin L., et al. Histological typing of endocrine tumours: WHO international histological classifi cationof tumors. – Berlin: Springer, 2000. – S. 223-245.
REFERENCES
1. Gorbunova V.A., Orel N.F., Kuzminov A.E. The modern trends treatment of neuroendocrine tumors // Sovremennaya onkologiya. – 2010. – №1. – P. 30-35. (in Russian)
2. Gurevich L.E., Delektorskaya V.V. Prospects for revision of the histological classification of neuroendocrine tumors // Sovremennaya onkologiya. – 2014. – No3. – P. 86-90. (in Russian)
3. Delektorskaya V.V., Kushlinskiy N.E. Neuroendocrine Tumors of Digestive System: Morphologic Spectrum and Cell Proliferation (КІ67 index) // Vestnik Rossiyskoy akademii meditsinskih nauk. – 2013. – №5. – P. 28-37. (in Russian)
4. Keplin M., Kvols L. Neuroendocrine tumors: Guidelines for doctors. – Moscow: Prakticheskaya meditsina, 2011. – 224 p. (in Russian)
5. Markovich A.A., Orel N.F., Lyubimova N.V. Biochemical Markers in Diagnostics and Treatment of Neuroendocrine Tumors // Voprosyi biologicheskoy, meditsinskoy i farmatsevticheskoy himii. – 2011. – №12. – P. 28-36. (in Russian)
6. Pinskiy S.B., Beloborodov V.A., Batoroev Yu.K., Dvornichenko V.V. Gastrointestinal neuroendocrine tumors (report 3). Neuroendocrine tumors of the stomach // Sibirskij Medicinskij Zurnal (Irkutsk). – 2015. – №1. – P. 17-24. (in Russian)
7. Pinskiy S.B., Beloborodov V.A., Batoroev Yu.K., Dvornichenko V.V. Gastrointestinal neuroendocrine tumors (report 4). Neuroendocrine tumors of the small intectine // Sibirskij Medicinskij Zurnal (Irkutsk). – 2015. – №2. – P. 10-16. (in Russian)
8. Bosman F., Carniero F., Hruban R., Tneise N. WHO Classification of Tumors of Digestive System – Lyon, IARC, Press. – 2010.
9. Boussaha T., Rougier P., Taieb J., Lepere C. Digestive neuroendocrine tumors (DNET): the era of targeted therapies // Clin Res Hepatol Gastroenterol. – 2013. – Vol.37. – P. 134-141.
10. Couvelard A. Ki67 and neuroendocrine tumors // Ann Pathol. – 2011. – Vol. 31 (5) Suppl. – P. S55-S56.
11. Jamali M., Chetty R. Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining. – Endocr Pathol. – 2008. – Vol. 19 (4). – P. 282-8.
12. Klimstra D., Modlin I., Adsay N., et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set // Am. J. Surg. Pathol. – 2010. – Vol. 34 (3). – P. 300-313.
13. Klimstra D.S. Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging // Semin Oncol. – 2013. – Vol. 40(1). – P. 23-36.
14. Klöppel G. Tumour biology and histopathology of neuroendocrine tumours // Best Pract Res Clin Endocrinol Metab. – 2007. – Vol. 21(1). – P. 15-31.
15. Klöppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms // Endocr Relat Cancer. – 2011. – Vol.18 (Suppl 1). – P. S1-16.
16. Klöppel G., Rindi G., Perren A., et al. The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement // Virchows Arch. – 2010. – Vol. 456(6). – P. 595-597.
17. Modlin I.M., Pavel M., Kidd M., Gustafsson B.I. Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours //Aliment Pharmacol Ther. – 2010. – Vol. 31(2). – P. 169-188.
18. Remes S.M., Tuominen V.J., Helin H., et al. Grading of neuroendocrine tumors with Ki-67 requires high-quality assessment practices // Am J Surg Pathol. – 2012. – Vol. 36(9). – P.1359-1363.
19. Rindi G., Klöppel G., Alhman H., et al. TNM staging of foregut (neuro) endocrine tumors: a consensus proposal including a grading system // Virchows Arch. – 2006. – Vol. 449(4). – P. 395-401.
20. Scoazec J.Y., Couvelard A. Gastroenteropancreatic neuroendocrine tumors: what must the pathologist know and do in 2014? // Ann Pathol. – 2014. – Vol. 34 (1). – P. 40-50.
21. Sidéris L., Dubé P., Rinke A. Antitumor effects of somatostatin analogs in neuroendocrine tumors // Oncologist. – 2012. – Vol. 17(6). – P. 747-755.
22. Solcia E., Kloppel G., Sobin L., et al. Histological typing of endocrine tumours: WHO international histological classifi cationof tumors. – Berlin: Springer, 2000. – S. 223-245.
Published
2018-04-16
How to Cite
БАТОРОЕВ, Юрий Климентьевич et al.
Morphology of neuroendocrine tumors of the digestive system.
Sibirskij Medicinskij Zurnal (Irkutsk) = Siberian Medical Journal (Irkutsk) 16+, [S.l.], v. 140, n. 1, p. 12-18, apr. 2018.
ISSN 1815-7572. Available at: <http://smj.ismu.baikal.ru/index.php/osn/article/view/189>. Date accessed: 01 jan. 2026.
Issue
Section
Scientific reviews
